Professor

Phone: 86-27-87792147

Email: qibingzhou@hust.edu.c

Academic Areas: Nanomedicine

Research Interests: Clinical translation of nanoparticles and nano-delivering systems for diagnosis and treatment of cancer

Academic Degrees

Ph.D

Professional Experience

09/2012 – 09/2016  Professor and Chair

Department of Nanomedicine and Biopharmaceuticals

Huazhong University of Science and Technology, Wuhan, China

 

06/2009 – present   Professor

National Engineering Research Center for Nanomedicine

Institute of Materia Medica, College of Life Science and Technology

Huazhong University of Science and Technology, Wuhan, China

 

Adjunct Professor

Department of Medicinal Chemistry

School of Pharmacy

Virginia Commonwealth University

 

08/2002 – 06/2009 Assistant Professor

Department of Chemistry

Virginia Commonwealth University, Richmond, VA, USA

 

12/1999 - 08/2002    Post-Doctoral Associate, University of Maryland, College Park, MD, USA

Selected Publications

1. Mosier PD, Chiang M-J, Lin Z, Jin Y, Althufiari B, Musayev F, Safo M, Zhou Q, Xie H*, Desai U R* (2016).Broad spectrum anti-influenza agents by inhibiting self-association of matrix protein 1. Sci Rep 6:32340.

2. Wei Y, Zhao M, Yang F, Mao Y, Xie H, Zhou Q* (2016) Iron overload by Superparamagnetic Iron Oxide Nanoparticles is a High Risk Factor in Cirrhosis by a Systems Toxicology Assessment. Sci Rep 6:29110

3. Zhang D, Liu H, Wei Q, Zhou Q* (2016) Structure-activity relationship study of anticancer thymidine-quinoxaline conjugates under the low radiance of long wavelength ultraviolet light for photodynamic therapy. Eur J Med Chem 107:180-191.

4. Wei Y, Liao R, Liu H, Li H, Xu H, Zhou Q* (2015) Biocompatible Low-retention SPIO Nanoclusters as Contrast Agents for MRI of Liver Tumor. J Biomed Nanotech 11:854-864.

5. Wei Q, Liu H, Zhang D, Zhou H, Zhang Z, Zhou Q* (2015) Anticancer Activity of a Thymidine Quinoxaline Conjugate is Modulated by Cytosolic Thymidine Pathways. BMC Cancer 15:159.

6. Wang X, Wang Z, Sidhu PS, Desai UR, Zhou Q* (2015) 6-Hydroxyflavone and Derivatives Exhibit Potent Anti-inflammatory Activity among Mono-, Di- and Polyhydroxylated Flavones in Kidney Mesangial Cells. PLoS ONE 10:e0116409.

7. Safo MK*, Musayev FN, Mosier PD, Zhou Q, Xie H*, Desai UR (2014) Crystal structures of influenza A virus matrix protein M1: Variations on a theme. PLoS ONE 9:e109510.

8. Sidhu PS, Zhou Q, Desai UR (2014) A simple, general approach of allosteric coagulation enzyme inhibition through monosulfated hydrophobic scaffolds. Bioorg Med Chem Lett 24:5716-5720.

9. Sidhu PS, Abdel AMH, Sarkar A, Mehta AY, Zhou Q, Desai UR* (2013) Designing allosteric regulators of thrombin. Exosite 2 features multiple subsites that can be targeted by sulfated small molecules for inducing inhibition. J Med Chem 56:5059-5070.

10. Mai L, Yao A, Li J, Wei Q, Yuchi M, He X, Ding M, Zhou Q* (2013) Cyanine 5.5 Conjugated Nanobubbles as a Tumor Selective Contrast Agent for Dual Ultrasound-Fluorescence Imaging in a Mouse Model. PLoS ONE 8:e61224.

11. Sidhu PS, Mosier PD, Zhou Q, Desai UR* (2013) On scaffold hopping: Challenges in the discovery of sulfated small molecules as mimetics of glycosaminoglycans. Bioorg Med Chem Lett 23:355-359.

12. Wei Q, Zhang D, Yao A, Mai L, Zhang  Z, Zhou Q* (2012) Design, Synthesis, and In vitro and In vivo Biological Studies of a 3’-Deoxythymidine Conjugate that Potentially Kills Cancer Cells Selectively. PLoS ONE 7:e52199.

13. Abdel AMH, Sidhu PS, Liang A, Kim JY, Mosier PD, Zhou Q, Farrell DH, Desai UR* (2012) Designing allosteric regulators of thrombin. Monosulfated benzofuran dimers selectively interact with Arg173 of exosite 2 to induce inhibition. J Med Chem 55:6888-6897.

14. Zhou Q*, Qu Y, Mangrum JB, Wang X (2011) DNA Alkylation with N-Methylquinolinium Quinone Methide to N2-dG Adducts Resulting in Extensive Stops in Primer Extension with DNA Polymerases and Subsequent Suppression of GFP Expression in A549 Cells. Chem Res Toxicol 24:402-411. 

15. Sidhu PS, Liang A, Mehta AY, Aziz MA, Zhou Q, Desai UR* (2011) Rational Design of Potent, Small, Synthetic Allosteric Inhibitors of Thrombin J Med Chem 54:5522–31.

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