Professor

Phone: 86-27-87742234

Email: yangxl@hust.edu.cn

Academic Areas: Nanomedicine

Research Interests: Nanopharmaceuticals, Nanobiomaterials, Nanobiodetetion, Nanodiagnostics

Academic Degrees

1991.9---1995.5 Huazhong University of Science & Technology, PhD, Biomedical Engineering

1989.9---1991.7  Huazhong University of Science & Technology, Master, Inorganic Chemistry

1984.9---1988.7 Huazhong University of Science & Technology, Bachelor, Applied Chemistry

Professional Experience

2007-present, Executive Vice Dean, School of Life Science and Technology, Huazhong University of Science & Technology, Wuhan, China;

2009.2-present, Director, National Engineering Research Center for Nanomedicine, China.

Selected Publications

[1] Huabing Chen, Hongda Zhu, Jingdong Hu, Yanbing Zhao, Qin Wang, Jiangling Wan, Yajiang Yang, Huibi Xu, and Xiangliang Yang, Highly compressed assembly of deformable nanogels into nanoscale suprastructures and their application in nanomedicine. ACS Nano, 2011, 5(4): 2671-2680.

[2] Yanbing Zhao, Chuansheng Zheng, Qin Wang, Jianlin Fang, Guofeng Zhou, Hui Zhao, Yajiang Yang, Huibi Xu, Gansheng Feng, Xiangliang Yang. Permanent and peripheral embolization: temperature-sensitive p(N-isopropylacrylamide-co-butyl methylacrylate) nanogel as a novel bloodvesselembolic material in the interventional therapy of liver tumors. Advanced Functional Materials, 2011, 21(11): 2035-2042.

[3] Ling Xiao, Xiaoqin Xiong, Xiaohui Sun, Yanhong Zhu, Hao Yang, Huabing Chen, Lu Gan, Huibi Xu, Xiangliang Yang. Role of cellular uptake in the reversal of multidrug resistance by PEG-b-PLA polymeric micelles. Biomaterials, 2011, 32(22): 5148-5157.

[4] Zhen Zhang, Xiaoqin Xiong, Jiangling Wan, Ling Xiao, Lu Gan, Youmei Feng, Huibi Xu, Xiangliang Yang. Cellular uptake and intracellular trafficking of PEG-b-PLA polymeric micelles. Biomaterials, 2012,33(29): 7233-7240

[5] Lingyu Jiang, Qing Zhou, Ketao Mu, Hui Xie, Yanhong Zhu, Wenzhen Zhu, Yanbing Zhao, Huibi Xu, and Xiangliang Yang, pH/temperature sensitive magnetic nanogels conjugated with Cy5.5-labled lactoferrin for MR and fluorescence imaging of glioma in rats. Biomaterials, 2013, 34(30): 7418-7428.

[6] Qin Wang, Di Zhang, Xiangliang Yang, Huibi Xu, Amy Q. Shen, and Yajiang Yang, Atom-economical in situ synthesis of BaSO4 as imaging contrast agents within poly(N-isopropylacrylamide) microgels using one-step droplet microfluidics. Green Chemistry, 2013, 15(8): 2222-2229.

[7] Zhihui Wan1, Huajian Mao1, Miao Guo, Yanli Li, Aijun Zhu, Hong Yang, Hui He, Junkang Shen, Lijuan Zhou, Zhen Jiang, Cuicui Ge, Xiaoyuan Chen, Xiangliang Yang, Gang Liu, Huabing Chen, Highly efficient hierarchical micelles integrating photothermal therapy and singlet oxygen-synergized chemotherapy for cancer eradication. Theranostics, 2014, 4(4): 399-411.

[8 ]Miao Guo, Huajian Mao, Yanli Li, Aijun Zhu, Hui He, Hong Yang, Yangyun Wang, Xin Tian, Cuicui Ge, Qiaoli Peng, Xiaoyong Wang, Xiangliang Yang, Xiaoyuan Chen, Gang Liu, and Huabing Chen, Dual imaging-guided photothermal/photodynamic therapy using micelles. Biomaterials, 2014, 35(16): 4656-4666.

[9] Yong’an Tang, Jun Hu, Ahmed H. Elmenoufy, and Xiangliang Yang, Highly efficient FRET system capable of deep photodynamic therapy established on X-ray excited mesoporous LaF3:Tb scintillating nanoparticles. ACS Applied Materials & Interfaces, 2015, 7(22): 12261-12269.

[10] Jun Hu, Yong'an Tang, Ahmed H. Elmenoufy, Huibi Xu, Zhen Cheng, and Xiangliang Yang, Nanocomposite-based photodynamic therapy strategies for deep tumor treatment. Small, 2015, 11(44): 5860-5887.

[11]  Yanli Li, Yibin Deng, Xin Tian, Hengte Ke, Miao Guo, Aijun Zhu, Tao Yang, Zhengqing Guo, Zhishen Ge, Xiangliang Yang, and Huabing Chen, Multipronged design of light-triggered nanoparticles to overcome cisplatin resistance for efficient ablation of resistant tumor. ACS Nano, 2015, 9(10): 9626-9637.

[12] Aijun Zhu, Ke Miao, Yibin Deng, Hengte Ke, Hui He, Tao Yang, Miao Guo, Yanli Li, Zhengqing Guo, Yangyun Wang, Xiangliang Yang, Youliang Zhao, and Huabing Chen, Dually pH/reduction-responsive vesicles for ultrahigh-contrast fluorescence imaging and thermo-chemotherapy-synergized tumor ablation. ACS Nano, 2015, 9(8): 7874-7885.

[13] Kun Qian, Yingying Ma, Jiangshan Wan, Shinan Geng, Han Li, Qianwen Fu, Xiaole Peng, Xuefeng Kan, Guofeng Zhou, Wei Liu, Bin Xiong, Yanbing Zhao, Chuansheng Zheng, Xiangliang Yang, and HuiBi Xu, The studies about doxorubicin-loaded p(N-isopropyl-acrylamide-co-butyl methylacrylate) temperature-sensitive nanogel dispersions on the application in TACE therapies for rabbit VX2 liver tumor. Journal of Controlled Release, 2015, 212: 41-49.

[14] Tao Yang, Yong Wang, Hengte Ke, Qiaoli Wang, Xiaoyan Lv, Hong Wu, Yongan Tang, Xiangliang Yang, Chunying Chen, Yuliang Zhao, and Huabing Chen, Protein-nanoreactor-assisted synthesis of semiconductor nanocrystals for efficient cancer theranostics. Advanced Materials, 2016, 28(28): 5923-5930.

[15] Yang Hao, Wang Qin, Huang Shan, Xiao Ai, Li Fuying, Gan Lu*, Yang Xiangliang. Smart pH/redox dual-responsive nanogels for on-demand intracellular anticancer drug release. ACS Applied Materials & Interfaces. 2016, 8 , 7729-7738.

 

Courses Taught

1. Nanomedicine

2. Nanopharmaceuticals

3. Introduction to Pharmaceutics

4. Fundamental of Pharmacology

Project

Center:

National Engineering Research Center for Nanomedicine

 

Programs:

[1] 973 Chief Scientist appointed by the Ministry of Science and Technology of China, National Key Scientific Program of China Project No. 2012CB932500, “The Studies of Novel Nanomedicine for the Treatment of Hepatocellular Carcinoma”, 2012.1-2016.9.

[2] Principle Investigator, National Natural Science Foundation of China, Project No. 81473171,“Strategy of Hydrophilic/Hydrophobic Reversal for the Biofate of Antineoplastic Agents based on Temperature/pH Nanogel”, 2015.01-2018.12.

[3] Principle Investigator, National Natural Science Foundation of China, Project No. 30873121, “Studies of Pharmacokinetics Model of Nanomedicine”, 2009.01-2011.12.

[4] Principle Investigator, National Natural Science Foundation of China , Project No. 30670662, “Quantum-Dot Based Novel Method of Homogenous Time-resolved Fluoroimmunoassy for the Prenatal Screening of Down's Syndrom” , 2007.01-2009.12.

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