Associate Professor

Phone: 0086-27-87792275-809,

Email: cmj@hust.edu.cn

Academic Areas: Biochemistry and Molecular Biology, Genetic Engineering and Genomics

Research Interests: Wheat quality improvement through genetic transformation

Academic Degrees

Ph.D., Biochemistry and Molecular Biology, Huazhong University of Science & Technology, P.R.China, 2005.

M.S., Microbiology, Wuhan Institute of Virology, Chinese Academy of Sciences, 1993.

B.S., Cellular Biology, University of Science and Technology of China, 1990.

 

Professional Experience

Associate Professor (2006-present), CHINA-UK HUST-RRES Genetic Engineering and Genomics Joint Laboratory, Huazhong University of Science and Technology,.

  • Wheat quality improvement through transformation of high-quality genes
  • Isolation of tissue-specific promoters in wheat

Ph.D. Candidate (2002-2005), College of Life Science and Technology, Huazhong University of Science and Technology

Visiting Scholar 2003-2004), Rothamsted Research, UK

Visiting Scholar 2000-2001), Ajou University School of Medicine, South Korea

Research Fellow 1993-2000), Department of Immunology, Wuhan Institute of Biological Products, P.R.China

Postgraduate (1990-1993), Wuhan Institute of Virology, Chinese Academy of Science

 

Selected Publications

1. Qiong Wang, Yin Li, Fusheng Sun, Xiaoyan Li, Pandi Wang, Jiutong Sun, Jian Zeng, Cheng Wang, Wei Hu, Junli Chang, Mingjie Chen, Yuesheng Wang, Kexiu Li, Guangxiao Yang*, Guangyuan He*. Tannins Improve Dough Mixing Properties through Affecting Physicochemical and Structural Properties of Wheat Gluten Proteins. Food Research International. 2015, 69: 64-71.

2. Qian Zheng, Yunyi Liu, Weiwei Liu, Fengyun Ma, Yi Zhou, Mingjie Chen, Junli Chang, Yuesheng Wang, Guangxiao Yang*, Guangyuan He*. Cucurbitacin B inhibits growth and induces apoptosis through the JAK2/STAT3 and MAPK pathways in SH-SY5Y human neuroblastoma cells. Molecular Medicine Reports, 2014, 10(1): 89-94. doi: 10.3892/mmr.2014.2175.

3. Qian Zheng, Weiwei Liu, Bin Li, Huijie Chen, Wenshan Zhu, Guangxiao Yang, Mingjie Chen*, Guangyuan He*. Anticancer Effect of Icaritin on Human Lung Cancer Cells through Inducing S Phase Cell Cycle Arrest and Apoptosis. J Huazhong Univ Sci Technol-Med, 2014, 34(4): 497-503.  Doi: 10.1007/s11596-014-1305-1

4. Amal M. Banafa, Sadia Roshan, Yunyi Liu, Shasha Zhao, Guangxiao Yang ,Guangyuan He, Mingjie Chen*. Fucoidan induces Apoptosis in MDA-MB-231 Cells by Activating Caspase Cascade and Down-regulating XIAP. Journal of Pharmacy and Biological Sciences, 2014, 9(3) : 59-64.

5. Sadia Roshan, Yunyi Liu, Amal Banafa, Huijie Chen, Kexiu Li, Guangxiao Yang,Guangyuan He, Mingjie Chen*. Fucoidan Induces Apoptosis of HepG2 Cells by Down-regulating p-Stat3. J Huazhong Univ Sci Technol-Med. 2014, 34(3):330-336. doi: 10.1007/s11596-014-1278-0

6. Sadia Roshan, Amal Banafa, Yun-yi LIU, Hui-jie CHEN, Guang-xiao YANG, Guang-yuan HE, Ming-jie CHEN*. The Anti-proliferative activity of fuciodan on numerous cancer cell lines. Journal of Pharmacy and Biological Sciences, 2014, 9(3): 30-36.

7. Z. Xiong, S. Zhao, X. Mao, X. Lua, G. He, G. Yang, M. Chen, M. Ishaq, K. Ostrikov. Selective neuronal differentiation of neural stem cells induced by nanosecond microplasma agitation. Stem Cell Research, 2014, 12, 387-399

8. Yin Li, Xiang Mao, Qiong Wang, Jinrui Zhang, Xiaoyan Li, Fengyun Ma, Fusheng Sun, Junli Chang, Mingjie Chen, Yuesheng Wang, Kexiu Li, Guangxiao Yang*, Guangyuan He*. Overexpression of Puroindoline a gene in transgenic durum wheat (Triticum turgidum ssp. durum) leads to a medium–hard kernel texture. Molecular Breeding, 2014, 33: 545-554.

9. Li S, Priceman SJ, Xin H, Zhang W, Deng J, Liu Y, Huang J, Zhu W, Chen M, Hu W, Deng X, Zhang J, Yu H, He G. Icaritin inhibits JAK/STAT3 signaling and growth of renal cell carcinoma. PLoS One, 2013, 8(12):e81657. doi: 10.1371/journal.pone.0081657.

10. Shasha Zhao, Zilan Xiong, Xiang Mao, Dandan Meng, Qian Lei, Yin Li, Pengyi Deng, Mingjie Chen, Min Tu, Xinpei Lu, Guangxiao Yang, Guangyuan He. Atmospheric Pressure Room Temperature Plasma Jets Facilitate Oxidative and Nitrative Stress and Lead toEndoplasmic Reticulum Stress Dependent Apoptosis in HepG2 Cells. PLOS ONE, AUG, 2013, 8( 8): e73665

11. Yunyi Liu, Wei Wang, Bin Fang, Fengyun Ma, Qian Zheng, Pengyi Deng, Shasha Zhao, Mingjie Chen, Guangxiao Yang* , Guangyuan He*.Anti-tumor effect of germacrone on human hepatoma cell lines through inducing G2/M cell cycle arrest and promoting apoptosis. European Journal of Pharmacology, 2013, 698 (1-3): 95-102.

12. Yun-yi LIU, Qian ZHENG, Bin FANG, Wei WANG, Feng-yun MA,Sadia Roshan, Amal Banafa, Ming-jie CHEN, Jun-li CHANG, Xiao-min DENG,  Ke-xiu LI, Guang-xiao YANG*,  Guang-yuan HE*. Germacrone Induces Apoptosis in Human Hepatoma HepG2 Cells through Inhibition of the JAK2/STAT3 Signalling Pathway. J Huazhong Univ Sci Technol[Med Sci], 2013, 33(3): 339-345.

13. Deng Pengyi, Wang Chen, Chen Liulin, Wang Cheng, Du Yuhan, Yan Xu, Chen Mingjie, Yang  Guangxiao*, He  Guangyuan*. Sesamin Induces Cell Cycle Arrest and Apoptosis through the Inhibition of Signal Transducer and Activator of Transcription 3 Signalling in Human Hepatocellular Carcinoma Cell Line HepG2. BIOLOGICAL & PHARMACEUTICAL BULLETIN, OCT 2013, 36( 10): 1540-1548

14. Amal M. Banafa, Sadia Roshan, Yun-yi LIU , Hui-jie CHEN, Ming-jie CHEN, Guang-xiao YANG*,  Guang-yuan HE*. Fucoidan Induces G1 Phase Arrest and Apoptosis through Caspases-dependent Pathway and ROS Induction in Human Breast Cancer MCF-7 Cells. J Huazhong Univ Sci Technol[Med Sci], 2013, 33(5): 717-724

15. Feng S, Song L, Liu Y, Lai F, Zuo G, He G, Chen M, Huang D. Hypoglycemic activities of commonly-used traditional Chinese herbs. Am J Chin Med, 2013, 41(4): 849-64. doi: 10.1142/S0192415X13500572.

16. Liu Y, Feng S, Song L, He G, Chen M, Huang D. Secondary metabolites in durian seeds: oligomeric proanthocyanidins. Molecules, 2013, 18(11): 14172-85. doi: 10.3390/molecules181114172.

17. Wang H, Song L, Feng S, Liu Y, Zuo G, Lai F, He G, Chen M, Huang D. Characterization of proanthocyanidins in stems of Polygonum multiflorum Thunb as strong starch hydrolase inhibitors. Molecules, 2013, 18(2):2255-65. doi: 10.3390/molecules18022255

18. Fengyun Ma, Miao Li, Tingting Li, Wei Liu, Yunyi Liu, Yin Li, Wei Hu, Qian Zheng, Yaqiong Wang, Kexiu Li, Junli Chang, Mingjie Chen, Guangxiao Yang, Yuesheng Wang*, Guangyuan He*. Overexpression of Avenin-like b proteins in bread wheat (Triticum aestivum L.) improves dough mixing properties by their incorporation into glutenin polymers. PLoS ONE, 2013, 8(7): 1-11(e66758).

19. Xiang Mao, Yin Li, Shasha Zhao, Jian Zhang, Qian Lei, Dandan Meng, Fengyun Ma, Wei Hu, Mingjie Chen, Junli Chang, Yuesheng Wang*, Guangxiao Yang*, Guangyuan He*. The Interactive Effects of Transgenically Overexpressed 1Ax1 with Various HMW-GS Combinations on Dough Quality by Introgression of Exogenous Subunits into an Elite Chinese Wheat Variety.  PLoS ONE, 2013, 8(10): 1-13(e78451).

20. Yin Li, Qiong Wang, Xiaoyan Li, Xin Xiao, Fusheng Sun, Cheng Wang, Wei Hu, Zhijuan Feng, Junli Chang, Mingjie Chen, Yuesheng Wang, Kexiu Li, Guangxiao Yang*, Guangyuan He*. Coexpression of the High Molecular Weight Glutenin Subunit 1Ax1 and Puroindoline Improves Dough Mixing Properties in Durum Wheat (Triticum turgidum L. ssp. durum).  PLoS ONE, 2012, 7(11): 1-12 (e50057).

21. Fei Song, Cui-Ju Cui, Ling Chen, Yang-Liu Sun, Fei-Fei Wang, Javeed Hussain, Yin Li, Chen Wang, Cheng Wang, Ming-Jie Chen, Yue-Sheng Wang, Guang-Xiao Yang, and Guang-Yuan He*. Isolation and Characterization of an Endosperm-Specific Promoter from Wheat (Triticum aestivum L.). Zeitschrift Fur Naturforschung Section C, 2012, 67(11-12): 611-619.

22. Wei Hu, Qianqian Yuan, Yan Wang, Rui Cai, Xiaomin Deng, Jie Wang, Shiyi Zhou, Mingjie Chen, Lihong Chen, Chao Huang, Zhanbing Ma, Guangxiao Yang* and Guangyuan He*. Overexpression of a Wheat Aquaporin Gene, TaAQP8, Enhances Salt Stress Tolerance in Transgenic Tobacco. Plant Cell Physiol. 2012, 53(12): 2127–2141.

23. Zhiyong Li; Zhaoshi Xu, Guangyuan He, Guangxiao Yang, Mingjie Chen, Liancheng Li, Youzhi Ma. Overexpression of soybean GmCBL1 enhances abiotic stress tolerance and promotes hypocotyl elongation in Arabidopsis. Biochemical and Biophysical Research Communications. 2012, 427(4): 731–736.

24. Li Z, Xu Z, He G, Yang G, Chen M, Li L, Ma Y.. A mutation in Arabidopsis BSK5 encoding a brassinosteroid-signaling kinase protein affects responses to salinity and abscisic acid. Biochemical and Biophysical Research Communications. 2012, 426(4): 522-527.

25. Yin Li., Qiong Wang., Xiaoyan Li, Xin Xiao, Fusheng Sun, Cheng Wang, Wei Hu, Zhijuan Feng, Junli Chang, Mingjie Chen, Yuesheng Wang, Kexiu Li, Guangxiao Yang*, Guangyuan He*. Coexpression of the High Molecular Weight Glutenin Subunit 1Ax1 and Puroindoline Improves Dough Mixing Properties in Durum Wheat (Triticum turgidum L. ssp. durum). PLOS ONE . 2012, 7 (11): 1-12 e50057.

26. Guangyuan He*, Jinrui Zhang, Kexiu Li, Zhiyong Xiong, Mingjie Chen, Junli Chang, Yuesheng Wang, Guangxiao Yang & Bea ta Barnaba. An improved system to establish highly embryogenic haploid cell and protoplast cultures from pollen calluses of maize (Zea mays L.). Plant Cell, Tissue and Organ Culture, 2006, 86:15-25.

27. Liting Luo, Mingjie Chen, Jue Wang, et al. The Molecular Evolution and Genome Sequence of Grain Hardness Genes in Genera of Triticeae dumort. Gluten Workshop, 2006.

28. Zhang J, Xiao Q, Li K, Chen M, Chang J, Luo L, Li Y, Liu Y, Shewry PR, He G. An optimal pooling strategy applied to high-throughput screening for rare marker-free transformants. Biotechnol Lett , 2006, 28(19): 1537-1544.

29. He G, Jones H., D’Ovidio R, Masci S, Chen M, West J, Butow B, Anderson OD, Lazzerif P, Fido R, Shewry PR. Expression of an extended HMW subunit in transgenic wheat and the effect on dough mixing properties. J Cereal Sci , 2005, 42(2):225-231.

30. Zhiming Tu, Guangyuan He, Kexiu Li, Mingjie Chen, Gang Lin. An improved system for competent cell preparation and high efficiency plasmid transformation using different Escherichia coli strains. Electronic Journal of Biotechnology, 2005, 8(1):113-120.

Courses Taught

0701262 Genomics

0706111 Cellular Engineering

Biochemistry Experiment

Project

1. Mechanism Research on Fucoidan’s Profective Effect on Neural Cells (Wuhan Municipal Science and Technology Research Project 201260523185)

2. Mechanism Research on Puroindolines’ Effect on Wheat Grain Hardness and Disease Resistance (Natural Science Foundation of Hubei Province 2011CDB370)

3. Function Research on Novel Genes of Wheat Grain Hardness (Natural Science Foundation of 30640043);

4. Food and Environment Safety Evaluation of Transgenic Wheat (Wuhan Municipal Science and Technology Research Project 200870834414)

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