Professor

Phone: 86-18154323093

Email: Bin_Zhu@hust.edu.cn

Academic Areas: Microbiology; Biochemistry; Biotechnology

Research Interests: Novel enzymes involved in nucleic acids metabolism;Marine molecular microbiology and biotechnology;Enzymatic synthesis of RNA and DNA

Academic Degrees

Ph. D., Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 2007

B. Sc., Xiamen University, 2002,

Professional Experience

2016-present, Professor  School of Life Science and Technology, Huazhong University of Science and Technology                                  

 007-2016, Research Fellow  Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School

 

Selected Publications

1. Zhu B*, Hernandez A, Tan M, Wollenhaupt J, Tabor S, Richardson CC. (2015) Synthesis of 2’-fluoro RNA by Syn5 RNA polymerase. Nucleic Acids Res. 43:e94 (*corresponding author)

2. Zhu B*, Tabor S, Richardson CC. (2014) Syn5 RNA polymerase synthesizes precise run-off RNA products. Nucleic Acids Res. 42: e33 (*corresponding author)

3. Zhu B*, Tabor S, Raytcheva DA, Hernandez A, King JA, Richardson CC*. (2013) The RNA polymerase of marine cyanophage Syn5. J. Biol. Chem. 288(5): 3545-3552 (*corresponding author)

4. Zhu B*, Lee SJ, Tan M, Wang ED, Richardson CC*. (2012) Gene 5.5 protein of bacteriophage T7 in complex with Escherichia coli nucleoid protein H-NS and transfer RNA masks transfer RNA priming in T7 DNA replication. Proc. Natl. Acad. Sci. USA 109(21): 8050-8055 (*corresponding author)

5. Zhu B. (2014) Bacteriophage T7 DNA polymerase - sequenase. Front. Microbiol. 5:181 (Review)

6. Zhu B, Lee SJ, Richardson CC. (2011) Bypass of a nick by the replisome of bacteriophage T7. J. Biol. Chem. 286(32): 28488-28497

7. Zhu B, Lee SJ, Richardson CC. (2010) Direct role for the RNA polymerase domain of T7 primase in primer delivery. Proc. Natl. Acad. Sci. USA 107(20): 9099-9104

8. Zhu B*, Lee SJ*, Richardson CC. (2009) An in trans interaction at the interface of the helicase and primase domains of the hexameric gene 4 protein of bacteriophage T7 modulates their activities. J. Biol. Chem. 284(35): 23842-52381 (*equal contribution)

9. Zhu B*, Yao P*, Tan M*, Eriani G, Wang ED. (2009) tRNA-independent pretransfer editing by class I leucyl-tRNA synthetase. J. Biol. Chem. 284(6): 3418-3424 (*equal contribution)

10. Zhu B, Zhao MW, Eriani G, Wang ED. (2007) A present-day aminoacyl-tRNA synthetase with ancestral editing properties. RNA 13(1): 15-21

11. Zhu B and Wang ED. (2007) Neurodegeneration-related aminoacyl-tRNA synthetases. Prog. Biochem. Biophys. 34(6): 562-566 (Review)

12. Tan M*, Zhu B*, Zhou XL, He R, Chen X, Eriani G, Wang ED. (2010) tRNA-dependent pre-transfer editing by prokaryotic leucyl-tRNA synthetase. J. Biol. Chem. 285(5): 3235-3244 (*equal contribution)

Project

2016 Chinese 1000 Young Talent Program;

2016 NSFC 31670175: Characterization and application of novel phage transcription systems

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