Professor

Phone: 027-87794006

Email: liming.chen@mail.hust.edu.cn

Academic Areas: Biophysics and Physiology of Acid-Base Transport

Research Interests: focuses on a group of Na+-coupled HCO3− transporters of SLC4 family. We are interested in the structure and function, functional regulation, protein interaction, physiological and pathological roles of these transporters

Academic Degrees

1997−2002, Ph.D., School of Life Sciences, Peking University

1993−1997, B.S., School of Life Sciences, Peking University

Professional Experience

2016−present: Professor, School of Life Sciences and Technology, HUST

2009−2015: Associate Professor, School of Life Sciences and Technology, HUST

2008−2009: Instructor, Department of Biophysics and Physiology, School of Medicine, Case Western Reserve University

2007−2008: Senior Research Associate, Department of Biophysics and Physiology, School of Medicine, Case Western Reserve University

2003−2007: Postdoctoral Associate, Department of Cellular and Molecular Physiology, School of Medicine, Yale University

2002−2003, Postdoc, School of Medicine, New York University

Selected Publications

1. Ying Liu, Xiao-Yu Wang, Zhang-Dong Xie, Li-Ming Chen*. Na+/HCO3 cotransporter NBCn1. Encyclopedia of Signaling Molecules, 2nd Edition. Edited by Sangdun Choi, Springer, 2016. (Invited chapter)

2. Li-Ming Chen, Mei Liu, Ying Liu*. Electrophysiology principles of Na+/HCO3 cotransporters. Acta Physiologica Sinica. 2016, 68(3): 323-334. DOI: 10.13294/j.aps.2016.0036

3. Ying Liu, Jichun Yang, Li-Ming Chen*. Structure and Function of SLC4 family HCO3 transporters. Frontiers in Physiology. 2015, 6:355. doi: 10.3389/fphys.2015.00355

4. Deng-Ke Wang§, Ying Liu§, Evan J. Myers, Yi-Min Guo, Zhang-Dong Xie, De-Zhi Jiang, Jia-Min Li, Jichun Yang, Mugen Liu, Mark D. Parker, Li-Ming Chen*. Effects of Nt-truncation and coexpression of isolated Nt domains on the membrane trafficking of electroneutral Na+/HCO3 cotransporters. Scientific Reports. 2015. 5: 12241, p.1−23. doi: 10.1038/srep12241. (§ Co-first author)

5. Ying Liu, Li-Ming Chen*. Towards bridging the gap between acid-base transporters and neuronal excitability modulation. International Journal of Physiology, Pathophysiology & Pharmacology. Invited Editorial. 2014; 6(4): 221-225. PMID: 25755844;

6. Yi-Min Guo, Ying Liu, Li-Ming Chen*. HCO3 reabsorption in proximal renal tubule: molecular mechanism and metabolic acidosis. Acta Physiologica Sinica. 2014 Aug 25;66(4):398-414b. doi: 10.13294/j.aps.2014.0047; PMID: 25131781.

7. Ying Liu, Xue Qin, Deng-Ke Wang, Yi-Min Guo, Harindarpal S. Gill, Nathan Morris, Mark D. Parker, Li-Ming Chen*, Walter F. Boron. Effects of optional structural elements, including two alternative amino termini and a new splicing cassette IV, on the function of NBCn1 (SLC4A7). The Journal of Physiology-London. 2013, 591(Pt 20):4983-5004. doi: 10.1113/jphysiol.2013.258673; PMID: 23959679.

8. Ying Liu, Deng-Ke Wang, De-Zhi Jiang, Xue Qin, Zhang-Dong Xie, Qing K. Wang, Mugen Liu, Li-Ming Chen*. Cloning and functional characterization of novel variants and tissue-specific expression of alternative amino and carboxyl termini of products of Slc4a10. PLoS ONE 2013; 8(2):e55974. doi: 10.1371/journal.pone.0055974; PMID: 23409100.

9. Ying Liu, Qun-Wei Lu, Li-Ming Chen*. Physiology and pathophysiology of Na/HCO3 cotransporter NBCe1. Acta Physiologica Sinica. 2012, 62(6):729-740. PMID: 23258339.

10. Li-Ming Chen*, Xue Qin, Fraser J. Moss, Ying Liu, Walter F. Boron*. Effect of simultaneously replacing putative TM6 and TM12 of human NBCe1-A with those from NBCn1 on surface abundance in Xenopus oocytes. Journal of Membrane Biology. 2012, 245(3): 131-40. doi: 10.1007/s00232-012-9421-y; PMID: 22383045.

11. Ying Liu, Deng-Ke Wang, Li-Ming Chen*. The physiology of bicarbonate transporters in mammalian reproduction. Biology of Reproduction. 2012, 86(4):99, 1-13. doi: 10.1095/biolreprod.111.096826; PMID: 22262691.

12. Ying Liu, Jiu-Ying Xu, Deng-Ke Wang, Lei Wang, Li-Ming Chen*. Cloning and identification of two novel NBCe1 splice variants from mouse reproductive tract tissues: A comparative study of NCBT genes. Genomics. 2011, 98:112-119. doi: 10.1016/j.ygeno.2011.04.010; PMID: 21600280.

13. Ying Liu, Jiu-Ying Xu, Deng-Ke Wang, Walter F. Boron, Li-Ming Chen*. Expression and distribution of NBCn2 (Slc4a10) splice variants in mouse brain: cloning of novel variant NBCn2-D. Brain Research, 2011, 1390:33-40. doi: 10.1016/j.brainres.2011.03.046; PMID: 21439947.

14. Li-Ming Chen*, Ying Liu, Walter F. Boron. Role of an extracellular loop in determining the stoichiometry of Na/HCO3 cotransporters. The Journal of Physiology-London, 2011, 589(4) 877-890. doi: 10.1113/jphysiol.2010.198713; PMID: 21224233.

15. Li-Ming Chen, Jinhua Zhao, Raif Musa-Aziz, Marc Pelletier, Ian A Drummond, Walter F Boron. Cloning and Characterization of a zebrafish cDNA homologue of human AQP1: A bifunctional water and gas channel. Am J Physiol Regul Integr Comp Physiol 2010, 299(5):R1163-74. doi: 10.1152/ajpregu.00319.2010; PMID: 20739606.

16. Ying Liu, Kui Xu, Li-Ming Chen, Xiuyan Sun, Mark D Parker, Michelle L Kelly, Joseph C LaManna, Walter F Boron. Distribution of NBCn2 (SLC4A10) splice variants in mouse brain. Neuroscience, 2010, 169(3):951-964. doi: 10.1016/j.neuroscience.2010.06.005; PMID: 20541593.

17. Raif Musa-Aziz, Lihong Jiang, Li-Ming Chen, KevineL Behar, Walter F Boron. Concentration-dependent effects on intracellular and surface pH of exposing Xenopus oocytes to solutions containing NH3/NH4+. Journal of Membrane Biology. 2009, 228(1):15-31. doi: 10.1007/s00232-009-9155-7; PMID: 19242745.

18. Walter F. Boron, Liming Chen, Mark D. Parker. Modular Structure of Sodium-Coupled Bicarbonate Transporters. The Journal of Experimental Biology. 2009, 212:1697-1706. (Invited Review).

19. Raif Musa-Aziz#, Li-Ming Chen#, Marc F Pelletier, Walter F Boron. Relative CO2/NH3 selectivities of AQP1, AQP4, AQP5, AmtB, and RhAG. Proc Natl Acad Sci USA, 2009, 106(13):5406-5411. (#Co-first author).

20. Li-Ming Chen*, Gabriel G Haddad, Walter F Boron. Effects of chronic continuous hypoxia on the expression of SLC4A8 (NDCBE) in neonatal versus adult mouse brain. Brain Research. 2008, 1238:85-92. doi: 10.1016/j.brainres.2008.08.033; PMID: 18775686.

21. Li-Ming Chen*, ML Kelly, MD Parker, HS Gill, JM Felie, BA Davis, WF Boron*. Expression and localization of Na+-driven Cl-HCO3 exchanger (SLC4A8) in rodent CNS. Neuroscience. 2008, 153(1):162-174. doi: 10.1016/j.neuroscience.2008.02.018; PMID: 18359573.

22. Li-Ming Chen*, Michelle L Kelly, Jose D Rojas, Mark D Parker, Harindarpal S Gill, Bruce A Davis, Walter F Boron. Use of a new polyclonal antibody to study the distribution and glycosylation of the sodium-coupled bicarbonate transporter NCBE in rodent brain. Neuroscience. 2008, 151(2):374-385. doi: 10.1016/j.neuroscience.2007.10.015; PMID: 18061361.

23. Li-Ming Chen*, Inyeong Choi, Gabriel G Haddad, Walter F Boron. Chronic continuous hypoxia decreases the expression of SLC4A7 (NBCn1) and SLC4A10 (NCBE) in mouse brain. Am J Physiol Regul Integr Comp Physiol. 2007, 293(6):R2412-20. doi: 10.1152/ajpregu.00497.2007; PMID: 17928512.

24. Volker Endeward, Raif Musa-Aziz, Gordon J Cooper, Li-Ming Chen, Marc F Pelletier, Leila V Virkki, Claudiu T Supuran, Landon S King, Walter F Boron, Gerolf Gros. Evidence that aquaporin 1 is the major pathway for CO2 transport across the human erythrocyte membrane. FASEB Journal, 2006, 20:1974-1981. doi: 10.1096/fj.04-3300com; PMID: 17012249.

25. Li-Ming Chen, Xing-Wen Yang, and Jian-Guo Tang. Expression of human prorelaxin H2 in Eschericia coli, protein purification and characterization. Acta Biochimica et Biophysica Sinica. 2002, 34(5)595-600. PMID: 12198562.

26. Li-Ming Chen, Xing-Wen Yang, and Jian-Guo Tang. Acidic residues on the N-terminus of proinsulin C-peptide are important for the folding of insulin precursor. Journal of Biochemistry (Tokyo), 2002, 131(6):855-859. PMID: 12038982.

 

Courses Taught

0700991  Biophysics for undergraduate students

0707291  Literature Reading and Academic Writing

170.550  Cellular Electrophysiology for graduate students

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