Professor

Phone: (027)87792025

Email: sgao@hust.edu.cn

Academic Areas: Neuroscience

Research Interests: Molecular and circuit mechanisms underlying behaviors;Synaptic plasticity and synapse development;Function and structure of ion channels, ion channelopathy

Academic Degrees

Ph.D. in Biophysics, 2008, Huazhong University of Sci.&Tech., China

B.S. in Biomedical Engineering, 2003, Huazhong University of Sci.&Tech., China

Professional Experience

Professor (2015 – present) Huazhong University of Sci.&Tech., China. Molecular and circuit mechanisms of behaviors

Postdoctoral Fellow (2008 – 2015), University of Toronto, Canada.

Selected Publications

1. Yu, W., Lin, X., Gao, S.#, Li, C.#, (2015) Age-related changes of inactivating BK channels in rat dorsal root ganglion neurons. J Neurol Sci. 358:138-45 ( #Corresponding authors)

2. Maro, G.S. *, Gao, S. *, Olechwier A.M., Hung W.L., Liu M., Özkan E., Zhen M. , Shen K. (2015) MADD-4/Punctin and Neurexin Organize C. elegans GABAergic Postsynapses through Neuroligin. Neuron, S0896-6273(15)00422-5.

3. Gao, S.#, Xie, L., Po, M.D., Guan, A., Zhen, M.#, (2015) The NCA sodium leak channel is required for persistent motor circuit activity that sustains locomotion. Nat. Commun. 6:6323.( #Corresponding authors)

4. Norris, A.D., Gao, S., Norris, M.L., Ray, D., Ramani, A.K., Fraser, A.G., Morris, Q., Hughes, T.R., Zhen, M., Calarco, J. (2014) A Pair of RNA-Binding Proteins Controls Networks of Splicing Events Contributing to Specialization of Neural Cell Types. Molecular Cell, S1097-2765(14).

5. Hung, W., Hwang, C., Gao, S., Liao, E., Chitturi, J., Wang, Y. Li, H., Stigloher, C., Bessereau, J.L. and Zhen, M. (2013) Attenuation of Insulin Signaling Contributes to FSN-1-mediated Regulation of Synapse Development. EMBO J, 32, 1745-1760.

6. Xie, L.*, Gao, S.*, Alcaire, S.M., Aoyagi, K., Wang, Y., Stagljar, I., Nagamatsu, S. and Zhen, M. (2013) NLF-1 Delivers a Sodium Leak Channel to Regulate Neuronal Excitability and Modulate Rhythmic Locomotion. Neuron, 77(6):1069-1082.

7. Gao, S. and Zhen, M. (2011) Action potentials drive body wall muscle contractions in Caenorhabditis elegans. Proc. Natl. Acad. Sci. U.S.A. 108(6) 2557-2562.

8. Kawano, T. *, Po, M.D. *, Gao, S., Leung, G., Ryu, W.S. And Zhen, M. (2011) An Imbalancing Act: Gap Junctions Reduce the Backward Motor Circuit Activity to Bias C. elegans for Forward Locomotion. Neuron 17 (4): 572-587.

9. Sancar, F. *, Touroutine, D. *, Gao, S.*, Oh, H.J., Gendrel, M., Bessereau, J., Kim, H., Zhen, M. and Richmond, J.E. (2011) The dystrophin-associated protein complex maintains muscle excitability by regulating BK channel localization. J. Biol. Chem. 286(38):33501-10.

10. Bouhours, M., Po, M.D., Gao, S., Hung, W., Li, H., Georgiou, J., Roder, J.C and Zhen, M. (2011) A Co-operative Regulation of Neuronal Excitability by UNC-7 Innexin and NCA/NALCN Leak Channel. Molecular Brain 4:16.

11. Gao, S. *, Fan, Y. *, Chen, L-Y., Lu, J-Z., Xu, T., Xu, P-Y. (2009) Mechanism of Different Spatial Distributions of C. elegans and Human STIM1 at Resting State. Cell Calcium 45, 77-88.

12. Zhang, L.*, Li, J-L.*, Gao, S.*, Wu, Z-X., Zhang, R-Y., Xu, T. (2009) Sec-10 Knockout Increases The Neuroactive-drug Responses Without Affecting Function of The Postsynaptic Ionotropic Receptors in Neuromuscular Junctions. Prog. in Biochem. and Biophys. 36(4): 410-416.

13. Gao, S. *, Wu, Y. *, Lv, C-X., Guo, Z-H., Li, C-H., Ding, J-P. (2008) Slack and Slick KNa channels are required for the depolarizing after potential of acutely isolated, medium diameter rat dorsal root ganglion neurons. Acta Pharmacologica Sinica 29(8):899-905.

14. Gao, S. *, Wang, C-M. *, Chen, X-S. *, Yu, W-W., Mo, B-W., Li, C-H. (2007) Cerebrosides of baifuzi, a novel potential blocker of Calcium-activated Chloride channels in rat pulmonary artery smooth muscle cells. Cell Biol Int. 31(9):908-15.

15. Li, W.*, Gao, S.*, Lv, C-X., Wu, Y., Guo, Z-H., Ding, J-P., Xu, T. (2007)  Characterization of Voltage- and Ca2+-Activated K+ Channels in Rat Dorsal Root Ganglion Neurons. J. Cell Physiol. 212(2):348-57.

Awards and Honors

National 1000-Young-Talent Program (2016 China).

Early Scholar Award (2009 Canada)

Courses Taught

170.904: Modern Experimental Techniques in Cellular Biophysics

Project

Neural circuit and molecular mechanisms of rhythmic locomotion in C. elegans (NSFC 31671052, 2017-2020)

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