Lecture

Phone: 13720184349

Email: slhuang@mail.hust.edu.cn

Academic Areas: Biophysics, Biochemistry

Research Interests: Protein oligomerization, receptor activation

Academic Degrees

PhD in Biophysics, 2009, Huazhong University of Science and Technology, Wuhan, China

BA in Genetics, 1995, Wuhan University, Wuhan, China

Professional Experience

Lecture (2011-2016): College of Life Science and Technology, HUST

Postdoc(2009-2011): College of Life Science and Technology, HUST

Selected Publications

1.      Zongyong Zhang, Wenhua Zhang, Siluo Huang*, Qian Sun, Yunyun Wang, Ping Hu, Ninghua Sun, Nagahiro Minato, Jean-Philippe Pin, Li Su*, Jianfeng Liu* GABAB receptor promotes its own surface expression by recruiting a Rap1-dependent signaling cascade. J Cell Sci, 2015  May, 128(12):2302-13   ISSN 0021-9533 5.432

2.      Zongyong Zhang*, Baoliang Sun, Junke Liu, Mingfeng Yang, Dawei Li, Jie Fang, Shuai Zhang, Qilin Yuan, Siluo Huang*. Activation of mGluR5 Attenuates Microglial Activation and Neuronal Apoptosis in Early Brain Injury After Experimental Subarachnoid Hemorrhage in Rats. Neurochem Res, 2015 May,  40:1121–1132

3.      Zongyong Zhang, Li Xue, Hui Guo, Ying Li, Haili Ding, Siluo Huang*. Phosphorylation-independent desensitization of Metabotropic Glutamate Receptor 5 by G Protein-coupled Receptor Kinase2 in HEK 293 cells. Mol Bio, 2013 Jan, (47): 137-146

4.      Guillaume Antony. Baloucoune, Lei Chun, Wenhua Zhang,  Chanjuan Xu, Siluo Huang, Yunyun Wang, Haijun Tu, Jianfeng Liu. GABAB Receptor subunit GB1 at the cell surface independently activates ERK1/2 through IGF-1R transactivation.  Plos One ,2012 June, 7(6): e39698

5.      Siluo Huang, Jianghua Cao, Ming,Jiang, Gilles Labesse, Jean-Philippe Pin, Jianfeng Liu, Philippe Rondard. Interdomain movements in metabotropic glutamate receptor activation. Proc Natl Acad Sci U S A. 2011 Sep, 108(37):15480-15485  

6.      Ming Jiang, Handong Ouyang, Pin Ruan, Han Zhao, Zhenjun Pi, Siluo Huang*, Ping Yi *, Michel Crepin. The chitosan derivatives inhibit cell proliferation and induce apoptosis in breast cancer cells. Anticancer Res, 2011 Apr, 31(4):1321-8

7.      Jianhua Cao, Siluo Huang, Ji Qian, Jinlin Huang, Li Jin, Zhixi Su,Ji Yang and Jianfeng Liu. Evolution of the class C GPCR Venus flytrap modules involved positive selected functional divergence. BMC Evo. Bio.,2009 Mar, 9:67(contribute equally as first authors)

8.      Arnaud Ahier, Philippe Rondard, Nadège Gouignard, Naji Khayath1, Siluo Huang, Jacques Trolet, Daniel J.Donoghue, Monique Gauthier, Jean-Philippe Pin, Colette Dissous. A new family of Receptor Tyrosine Kinases with a Venus Flytrap binding domain in insects and other invertebrates activated by aminoacids.Plos One,2009 May, 4(5) ,e5651.

9.      Philippe Rondard,Siluo Huang, Carine Monnier, Haijun Tu, Bertrand Blanchard,Nadia Oueslati, Fanny Malhaire, Ying Li,Eric Trinquet, Gilles Labesse, Jean-Philippe Pin, and Jianfeng Liu. Functioning of the dimeric GABAB receptor extracellular domain revealed by glycan wedge scanning. EMBO J.,2008 May,27, 1321-32(contribute equally as first authors)

10.   Philippe Rondard, Jianfeng Liu, Siluo Huang, Fanny Malhaire, Claire Vol, Alexia Pinault, Gilles Labesse,and Jean-Philippe Pin.Coupling of agonist binding to effector domain activation in metabotropic glutamate-like receptors. J. Biol. Chem ,2006 Aug, 281,24653-24661

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