Phone: 027-87792024


Academic Areas: Angiogenesis, vascular remodeling

Research Interests: Mechanism of endoplasmic reticulum stress-induced vascular endothelial dysfunction;Study of mechanosensors on the endothelium by microfluidic technology

Academic Degrees

PhD in Biologic and Medical engineering, 2002, University of Paris 13, France

BA Biochemistry, 1996, WuHan University, Wuhan, Hubei, China


Professional Experience

Professor (2010-present); College of Life Science & Technology, Huazhong University of Science and Technology, Wuhan, Hubei, China

Research Engineer (2008-2013); Institute of Natural Product Chemistry, Centre national de la recherche scientifique UPR 2301, Gif-sur-Yvette, France

Selected Publications

1. Liu JM, Lawrence F, Kovacevic M, Bignon J, Papadimitriou E, Lallemand JY, Katsoris P, Potier P, Fromes Y, Wdzieczak-Bakala J. The tetrapeptide AcSDKP, an inhibitor of primitive hematopoietic cell proliferation, induces angiogenesis in vitro and in vivo. Blood, 101 (8): 3014-3020, 2003.

2. Liu JM, Garcia-Alvarez MC, Bignon J, Kusinski M, Kuzdak K, Riches A, Wdzieczak-Bakala J. Overexpression of the natural tetrapeptide acetyl-N-ser-asp-lys-pro derived from thymosin beta4 in neoplastic diseases. Ann N Y Acad Sci., 1194:53-9, 2010.

3. Wang L, Zhang ZL, Wdzieczak-Bakala J, Pang DW, Liu JÜ and Chen YÜ. Patterning cells and shear flow conditions: Convenient observation of endothelial cell remoulding, enhanced production of angiogenesis factors and drug response. Lab Chip. 11(24): 4235-40, 2011.

4. Hu P, Li B, Zhang W, Li Y, Li G, Jiang X, Wdzieczak-Bakala J, Liu JÜ. AcSDKP regulates Cell Proliferation through the PI3KCA/Akt Signaling Pathway. PLoS One. 8(11): e79321, 2013.

5. Jia L, Cui D, Bignon J, Di-Cicco A, Wdzieczak-Bakala J, Liu JÜ, Li MHÜ. Reduction-Responsive Cholesterol-Based Block Copolymer Vesicles for Drug Delivery. Biomacromolecules, 15(6): 2206-17, 2014.


1. Expression and mechanism of a tetra-peptide Acetyl-Ser-Asp-Lys-Pro (AcSDKP) in the occurrence, metastasis and angiogenesis of glioma progression (NSCF 30901816, 2010-2012).

2. Interaction and mechanism of anti-cancer lead drugs and FAK protein by EFI mass spectrometry (NSCF 21275167, 2013-2016).

3. Construction of tissue microfluidic chip for the study of tumor angiogenesis (Independent innovation research foundation of Huazhong University of Science and Technology , 2014)

4. Investigation of the mechanistic effects of AcSDKP upon post-injury vascular remodeling via utilizing the microfluidic technology (NSCF 91539107, 2016-2018).

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