Professor

Phone: 027-87792337

Email: ibbwuzx@mail.hust.edu.cn

Academic Areas: Neurobiology and biophysics.

Research Interests: Our studies focus on sensory signaling, regulation of sensations, learning and memory, decision making and the molecular mechanisms and neuronal circuits underlying these neuronal activities, using C. elegans as a model.

Academic Degrees

2005, Ph.D. in Biophysics, School of Life Science and Technology, HuaZhong University of Science and Technology, Wuhan, China.

1990, M.S. in Physiology, Department of Biology, SiChuan University, Chengdu, China.

1984, B.S. in Biology, Department of Biology, HuaZhong Normal University, Wuhan, China.

Professional Experience

2008–present, full professor, College of Life Science and Technology, HuaZhong University of Science and Technology, Wuhan, China.

2005–2008, associate professor, College of Life Science and Technology, HuanZhong University of Science and Technology, Wuhan, China.

2002-2004, visiting scholar at Physiologisches Institut, Universitaet des Saarlandes, Homburg, Saarland, Germany.

2000–2005, Lecturer, College of Life Science and Technology, HuaZhong University of Science and Technology, Wuhan, China.

1984–1984, assistant professor in Physiology, HuNan University ShaoYang Branch (Now, ShaoYang University), ShaoYang, Hunan Province, China.

Selected Publications

1. Wang W., Qin L.W., Wu T.H., Ge C.L., Wu Y.Q., Zhang Q., Song Y.X., Chen Y.H., Ge M.H., Wu J.J., Liu H., Xu Y., Su C.M., Li L.L., Tang J., Li Z.Y., Wu Z.X., cGMP Signalling Mediates Water Sensation (Hydrosensation) and Hydrotaxis in Caenorhabditis elegans. Sci. Rep., 2016, 6, 19779.

2. Hou P.P., Xiao F., Liu H.W., Ming Y.C., Zhang G.H., Wu, Y., Wang W., Zeng W.P., Ding M.Y., Cui J.M., Wu Z.X., Wang L.Y., Ding J. P., Extrapolating microdomain Ca2+ dynamics using BK channels as a Ca2+ sensor. Sci. Rep., 2016 6, 17343.

3. Guo M., Wu T.H., Song Y.X., Ge M.H., Su C.M., Niu W.P., Li L.L., Xu Z.J., Ge C.L., Al-Mhanawi, M.T.H., Wu S.P., Wu Z.X., Reciprocal inhibition between sensory ASH and ASI neurons modulates nociception and avoidance in Caenorhabditis elegans. Nat. Commun., 2015, 6: 13.

4. Wang W., Xu Z.J., Wu Y.Q., Qin, L.W., Li Z.-Y., Wu, Z.X., Off-response in ASH neurons evoked by CuSO4 requires the TRP channel OSM-9 in Caenorhabditis elegans. Biochem. Biophys. Res. Commun., 2015, 461, 463-468.

5. Huang, W.M., Li, Z.Y., Xu, Y.J., Wang, W., Zhou, M.G., Zhang, P., Liu, P.S., Xu, T., and Wu, Z.X. PKG and NHR-49 signalling co-ordinately regulate short-term fasting-induced lysosomal lipid accumulation in C. elegans. Biochem. J., 2014, 461(3): 509-520.

6. Meng L.F., Chen L., Li Z.Y., Wu Z.X., Shan G., Environmental RNA interference in animals. Chinese Sci Bull, 2013, 58(35), 4418-4425.

7. Meng L.F., Chen L., Li Z.Y., Wu Z.X., Shan G., Roles of MicroRNAs in the Caenorhabditis elegans Nervous System. J. Genet. Genomics, 2013, 40(9), 445-452.

8. Li Z.Y., Li Y.D., Yi Y.L., Huang W.M., Yang S., Niu W.P., Zhang L., Xu Z.J., Qu, A.L., Wu, Z.X. Xu T., Dissecting a central flip-flop circuit that integrates contradictory sensory cues in C. elegans feeding regulation. Nat. Commun. 2012, 3, 776.

9. Qu F., Chen Z.B., Wang X.X., Meng L.F., Wu Z.X., Qu, A.L., (). Observing GLUT4 Translocation in Live L6 Cells Using Quantum Dots. 2011, Sensors, 11(2), 2077-2089.

10. Lin X.G., Ming M., Chen M.R., Niu W.P., Zhang Y.D., Liu B., Jiu Y.M., Yu J.W., Xu T., Wu, Z.X., UNC-31/CAPS docks and primes dense core vesicles in C. elegans neurons. Biochem. Biophys. Res. Commun., 2010, 397, 526-531.

11. Chen M.R. Yang S., Niu W.P., Li Z.Y., Meng L.F., Wu Z.X. A novel fluorescent timer based on bicistronic expression strategy in Caenorhabditis elegans. Biochem. Biophys. Res. Commun., 2010, 395(1): 82–86.

12. Jiu Y.M., Yue Y., Yang S., Liu L., Yu J.W., Wu Z.X., Xu, T., Insulin-like signaling pathway functions in integrative response to an olfactory and a gustatory stimuli in Caenorhabditis elegans. Protein & cell, 2010, 1(1), 75-81.

13. Li Z.Y., Zhou W., Wu Z.X., Zhang R.Y., Xu T., Fabrication of size-controllable ultrasmall-disk electrode: Monitoring single vesicle release kinetics at tiny structures with high patio-temporal resolution. Biosens. Bioelectron., 2009, 24(5), 1358-1364.

14. Zhang H., Luo J., Xiong J., Lin X.G., Wu Z.X., Qu, A.L., Zf- and Hsys-based Cm measurement under the whole-cell patch-clamp recording. Eur. J. Phy., 2009, 457(6), 1423-1434.

15. Hu Z.T., Chen M.R., Zhao P., Dong Y.M., Zhang R.Y., Xu T., Wu Z.X. Synaptotagmin IV regulates dense core vesicle (DCV) release in LβT2 cells. Biochem. Biophys. Res. Commun., 2008 371(4), 781-786.

16. Zhou K.M., Dong Y.M., Ge Q., Zhu D., Zhou W., Lin X.G., Liang T., Wu Z.X., Xu T., PKA activation bypasses the requirement for UNC-31 in the docking of dense core vesicles from C. elegans neurons. Neuron, 2007, 56(4), 657–669.

17. Zhu D., Zhou W., Liang T., Yang F., Zhang R.Y., Wu Z.X., Xu, T.,. Synaptotagmin I and IX function redundantly in controlling fusion pore of large dense core vesicles. Biochem. Biophys. Res. Commun., 2007(4), 361, 922-927.

18. Xiong X., Zhou K.M., Wu Z.X., Xu, T., Silence of synaptotagmin I in INS-1 cells inhibits fast exocytosis and fast endocytosis. Biochem. Biophys. Res. Commun., 2006, 347(1), 76-82.

19. Stevens D.R., Wu Z.X., Matti U., Junge H.J., Schirra C., Becherer U., Wojcik S.M., Brose N., Rettig J., Identification of the minimal protein domain required for priming activity of Munc13-1. Curr. Biol., 2005, 15(24), 2243-2248.

20. Liu H.S., Hu Z.T., Zhou K.M., Jiu Y.M., Yang H., Wu Z.X., Xu T., Heterogeneity of the Ca2+ sensitivity of secretion in a pituitary gonadotrope cell line and its modulation by protein kinase C and Ca2+. J. cell. physiol., 2006, 207(3), 668-674.

21. Tian J.H., Wu Z.X., Unzicker M., Lu L., Cai Q., Li C., Schirra C., Matti U., Stevens D., Deng C., Rettig J., Sheng Z.H., The role of Snapin in neurosecretion: snapin knock-out mice exhibit impaired calcium-dependent exocytosis of large dense-core vesicles in chromaffin cells. J. Neurosci., 2005, 25(45), 10546-10555.

22. Wu Z.X., Xia S., Xu L., Bai L., Xu T., Dynamic imaging of single secretory granule in cultured PC12 cells. Acta Bioch. Bioph. Sin., 2003, 35 (4), 381-386.

Courses Taught

170.552: Advanced Neurobiology for Gradate

0701031: Neurobiology for Undergraduate

 

Project

1. Studies on Neuronal circuits and modulation of hygro-sensation and hygro-aversion in C. elegans. National Natural Science Foundation of China, 31471034, 2015–2018.

2. The regulation of CAPS on vesicular exocytosis and underlying mechanisms. National Natural Science Foundation of China, 31471034, 2015–2018. National Natural Science Foundation of China, 30770523, 2008–2010.

3. The molecular mechanisms underlying the calcium dependence and the regulation of secretion. National Natural Science Foundation of China, 30670502, 2007–2009.

4. Systemic studies on signal transduction networks in Metabolic physiological activities and pathological process. National Basic Research Program of China, National Basic Research Program of China, 2011CB910200, 2011–2015

5. The studies on the molecular mechanisms and functions of dynamic changes of bio-membranes. National Basic Research Program of China, National Basic Research Program of China, 2010CB833700, 2010–2014

6.The systems biology studies of functional systems of model organisms and cells. National Basic Research Program of China, National Basic Research Program of China, 2006CB910700, 2006–2010

7. The studies on molecular and cellular mechanisms of insulin parasecretion. National Basic Research Program of China, National Basic Research Program of China, National Basic Research Program of China, National Basic Research Program of China, 2006CB910700, 2006–2010

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