Professor

Phone: 027-87792510

Email: lhong@mail.hust.edu.cn

Academic Areas: Studying major and rare human diseases using both human and model organism such as Drosophila, Mouse

Research Interests: Cancer and Metabolism

Academic Degrees

Ph.D

Professional Experience

2007-present , Huazhong University of Science and Technology, College of Life Science and Technology

Selected Publications

1) Fengsen Duan, Yuejin Yu, Rijian Guan, Zhiliang Xu, Huageng Liang*, Ling Hong* (2016) “Vitamin K2 Induces Mitochondria-Related Apoptosis in Human Bladder Cancer Cells via ROS and JNK/p38 MAPK Signal Pathways” PLoS ONE 11(8): e0161886. doi:10.1371/journal.pone.0161886

2)Yan Xia, Samira Zohra Midoun, Zhiliang Xu and Ling Hong* (2015) “Heixuedian (heix), a potential melanotic tumor suppressor gene, exhibits specific spatial and temporal expression pattern during Drosophila hematopoiesis” Developmental Biology 398,218-230

3)Junli Liu & Dongxin Zhang & Ling Hong* (2014)“Isolation, characterization and functional annotation of the salt tolerance genes through screening the high-quality cDNA library of the halophytic green alga Dunaliella salina (Chlorophyta)”, Ann Microbiol, DOI 10.1007/s13213-014-0967-z

4)夏炎枝,红凌* (2013)“膜蛋白UBIAD1 在生物医学中的功能研究进展”,医学分子生物学杂志,10(4),220-225 (DOI: 10.3870/1672-8009.2013.04.007)

5) Xian Wang, Dangfeng Wang, Pan Jing, Yuangan Wu, Yanzhi Xia, Maorong Chen and Ling Hong* (2013) “A novel Golgi retention signal RPWS for tumor suppressor UBIAD1” Plos One  Aug 19; 8(8): e72015

6) 解举民,段峰森,夏炎枝,红凌* (2012) “TERE1(UBIAD1)基因对膀胱癌细胞系T24凋亡的影响” 中国现代医学杂志 22(17), 1-5

7) 夏炎枝,赵为,魏雄,吴时敏,王西明,红凌* (2011)“移行上皮反应基因TERE1的结构与功能分析”,中国现代医学杂志, 08期, pp 913-918 期刊论文

8) *赵为,夏炎枝,肖菡,夏燕,李欣玥,红凌* (2011)“果蝇heix基因启动子的分析及其转录活性鉴定”,武汉大学学报, 57(1), pp 52-56 期刊论文

9) Xia Yanzhi, Wei Xiong, Shimin Wu, Bo Wang, Ximing Wang* and Ling Hong**. (2010) “Down-regulation of TERE1/UBIAD1 activated Ras-MAPK signaling and induced cell proliferation”, Cell Biol. Int. Rep. 17(1):19-26 art:e00005.doi:10.1042/CBR20100005.

10) Yanzhi Xia* and Ling Hong** (2010)“Molecular mechanism of the inhibition of TERE1/UBIAD 1 in bladder carcinoma” Eighth International Symposium on Frontiers of Life Sciences: New Advances and Challenges in Multidisciplinary Research, 2010/8/25.(SCI)

11) *Zhu Y, Zhu J, Wang F, Zhang T** and Ling Hong** (2010)“Expression of TERE 1 in normal forelimbs development and retinoic acid-induced short limb malformations in mouse embryogenesis” 环境与职业医学, 27(12), pp 731-734, 2010/12.。期刊论文

12)夏炎枝,红凌* “蛋白质异戊烯化修饰与抗肿瘤研究”医学分子生物学杂志 期刊论文

13)朱勇飞,朱江波,王飞,红凌*,张天宝(2010)“TERE1基因在小鼠胚胎腭发育和腭裂形成中的表达”毒理学杂志, 04期, 2010/8/25.。期刊论文

14)张翅,戴国飞,刘军立,夏炎枝,甘南琴,红凌*(2009)“盐胁迫下杜氏盐藻(Dunaliella salina)cDNA文库的构建与新表达序列标签(EST)的获取、分析”武汉大学学报(理学版), 03期,  6/24.。期刊论文

15) Rubin, G.M*., L. Hong, P. Brokstein, M. Evans-Holm, E. Frise, M. Stapleton and D. A. Harvey (2000) " A Drosophila Complementary DNA Resource” Science 287: 2222-2224

16) Hong, L. and R.B. Hallick*, (1994) "A Group III Intron is formed from Domains of Two Individual Group II Introns", Genes & Dev  8:1589-1599.

17) MGC Program Team (......Gerald M. Rubin, Ling Hong, Mark Stapleton,......)Generation and Initial Analysis of more than 15,000 Full-length Human and Mouse cDNA Sequences PNAS (2002), 16899-16903

18) Stapleton, M, G. Liao, P. Brokstein, L.Hong, P. Carninci, T. Shiraki, Y. Hayashizaki, M. Champe, J. Pacleb, K. Wan, C. Yu, J. Carlson, R. George, S. Celniker, and G. Rubin (2002) “The Drosophila Gene Collection: identification of putative full-length cDNAs for 70% of D. melanogaster genes.” Genome Research  12:1294-1300.

19) Ashburner, M, S. Misra, J. Roote, S. E. Lewis, R. Blazej, T. Davis, C. Doyle, R. Galle, R. George, N. Harris, G. Hartzell, D. Harvey, L. Hong, K. Houston, R. Hoskins, G. Johnson, C. Martin, A. Moshrefi, M. Palazzolo, M. G. Reese, A. Spradling, G. Tsang, K. Wan, K. Whitelaw, B. Kimmel, S. Celniker, and G. M. Rubin, " An exploration of the sequence of a 2.9-Mb region of the genome of Drosophila melanogaster: The Adh Region” (1999) Genetics  153: 179-219

20) Hong, L, J.K. Stevenson, W.B. Roth, and R.B. Hallick, (1995) "Euglena gracilis chloroplast psbB, ycf8, psbH and psbN gene cluster: Regulation of psbB-ycf8 pre-mRNA processing", Mol Gen Genet  247: 180-188.
 

21) Jenkins, K.P., L. Hong, and R.B. Hallick, (1995) "Alternative splicing of the Euglena gracilis chloroplast roaA transcript", RNA  6: 624-633

22) Thompson, M.D., L. Zhang, L. Hong, and R.B. Hallick, (1997) "Extensive structural conservation exists among several homologs of two Euglena chloroplast group II introns” Mol Gen Genet  257: 45-54

23) Thompson, M.D., L. Zhang, L. Hong, and R.B. Hallick, (1997) "Two new group-II twintrons in the Euglena gracilis chloroplast are absent in basally branching Euglena species", Current Genetics 31:89-95.

24) Hong, L. and R.B. Hallick, (1994) "Gene structure and expression of a novel Euglena gracilis chloroplast operon encoding cytochrome b6 and the ß subunits of the H+-ATP synthase complex", Current Genetics 25:270-281.

25) Hallick, R.B., L. Hong, R.G. Drager, M.R. Favreau, A. Montfort, B. Orsat, A. Spielmann, and E. Stutz, (1993) "Complete Sequence of Euglena gracilis Chloroplast DNA" Nucleic Acids Res. 15:3537-3544.

Courses Taught

(Undergraduate), Molecular & Cell Biology (MCB graduate)

Project

Key Laboratory of Molecular Biophysics for Ministry of Education

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