Professor

Phone: 862787794549

Email: lium@hust.edu.cn

Academic Areas: Human Molecular genetics

Research Interests: 1, Identification pathogenic genes for inheritance diseases; 2, Animal models and molecular mechanism studies for eye diseases and skin defects; 3, Precision treatment studies for inheritance disease.

Academic Degrees

Ph.D.in Genetics, 2003, Fudan University

Bachelor degree in Biology, 1990, Nanjing Normal University

Professional Experience

2006-present, Professor, College of Life Sci. and Tech., Huazhong University of Sci. and Tech.

2003-2006, Associate Professor, College of Life Sci. and Tech., Huazhong University of Sci. and Tech.

1991-2000, Department of biology, School of medicine, Jiangsu University, assistant, lecturer

Selected Publications

1. Wang J, Liu Y, Liu F, Huang C, Han S, Lv Y, Liu CJ, Zhang S, Qin Y, Ling L, Gao M, Yu S, Li C, Huang M, Liao S, Hu X, Lu Z, Liu X, Jiang T, Tang Z, Zhang H, Guo AY, Liu M. Loss-of-function Mutation in PMVK Causes Autosomal Dominant Disseminated Superficial Porokeratosis. Sci Rep. 2016 Apr 7;6:24226.

2. Liu F, Chen J, Yu S, Raghupathy RK, Liu X, Qin Y, Li C, Huang M, Liao S, Wang J, Zou J, Shu X, Tang Z, Liu M. Knockout of RP2 decreases GRK1 and rod transducin subunits and leads to photoreceptor degeneration in zebrafish. Hum Mol Genet. 2015 Aug 15;24(16):4648-59. 

3. Huang M, Li D, Huang Y, Cui X, Liao S, Wang J, Liu F, Li C, Gao M, Chen J, Tang Z, Li DW, Liu M. HSF4 promotes G1/S arrest in human lens epithelial cells by stabilizing p53. Biochim Biophys Acta. 2015 Aug;1850(8):1808-17.

4. Chen J, Liu F, Li H, Archacki S, Gao M, Liu Y, Liao S, Huang M, Wang J, Yu S, Li C, Tang Z, Liu M. pVHL interacts with Ceramide kinase like (CERKL) protein and ubiquitinates it for oxygen dependent proteasomal degradation. Cell Signal. 2015 Nov;27(11):2314-23.

5. Li C, Wang L, Zhang J, Huang M, Wong F, Liu X, Liu F, Cui X, Yang G, Chen J, Liu Y, Wang J, Liao S, Gao M, Hu X, Shu X, Wang Q, Yin Z, Tang Z, Liu M. CERKL interacts with mitochondrial TRX2 and protects retinal cells from oxidative stress-induced apoptosis. Biochim Biophys Acta. 2014 Jul;1842(7):1121-9.

6. Cai-E Zhang, Duanzhuo Li, Jian-Guo Zhang, Xing-Ping Chen, Mi Huang, Stephen Archacki, Yu-Ke Tian, Wei-Ping Ren, Ai-Hua Mei, Qing-Yan Zhang, Ming-Yan Fang, Zheng Su, Xiukun Cui, Huan-Ming Yang, Qing Wang , Jun Wang, Mugen Liu, Yun-Hua Deng, Mutations in ABCB6 Cause Dyschromatosis Universalis Hereditaria, Journal of Investigative Dermatology. 2013 Sep;133(9):2221-8.

7. Cui X, Wang L, Zhang J, Du R, Liao S, Li D, Li C, Ke T, Li DW, Huang H, Yin Z, Tang Z, Liu M. HSF4 Regulates DLAD Expression and Promotes Lens De-nucleation. (BBA) - Molecular Basis of Disease. 2013 Aug;1832(8):1167-72

8. Tang Z, Wang Z, Wang Z, Ke T, Wang QK, Liu M. Novel compound heterozygous mutations in CERKL cause autosomal recessive retinitis pigmentosa in a nonconsanguineous Chinese family. Arch Ophthalmol. 2009 Aug;127(8):1077-8

9. Liu P, Zhang S, Yao Q, Liu X, Wang X, Huang C, Huang X, Wang P, Yuan M, Liu JY, Wang QK, Liu M. Identification of a genetic locus for autosomal dominant disseminated superficial actinic porokeratosis on chromosome 1p31.3-p31.1.Hum Genet. 2008 Jun;123(5):507-13

10. Zhang S, Wang, L, Hao Y, Wang P, Hap P, Yin K, Wang QK, and Liu M. (2008) T14484C and T14502C in the mitochondrial ND6 gene are associated with Leber's hereditary optic neuropathy in a Chinese family.  Mitochondrion. 2008 Jun;8(3):205-10.

11. Mugen Liu, Tie Ke, Zhaoxiang Wang, Qinbo Yang, Wei Chang, Fagang Jiang, Zhaohui Tang. Hui Li, Xiang Ren, Xu Wang, Tao Wang, Qingchun Li, Junguo Yang, Jingyu Liu, Qing K Wang. Identification of a CRYAB mutation associated with autosomal dominant posterior polar cataract in a Chinese family. Invest Ophth Vis Sci. 2006 47(8):3461-3466

12. Xu Wang, Fuying Xiao, Qinbo Yang, Bo Liang, Zhaohui Tang, Linbin Jiang, Qihui Zhu, Wei Chang, Jiuxi Jiang, Chuanming Jiang, Xiang Ren, Jingyu Liu, Qing Wang, Mugen Liu. 2006, A Novel Mutation in GDF5 Causes Autosomal Dominant Symphalangism in Two Chinese Families. Am J Med Genet. 140(17):1846-53

13. Tie Ke, Binchu Ji, Xu Wang, Ping Liu, Xianqin Zhang, Zhaohui Tang, Xiang Ren, Qing k. Wang, Mugen Liu. Novel HSF4 Mutation Causes Congenital Total White Cataract in a Chinese Family. Am J Ophthalmol. 2006 142(2):298-303

14. Xiao-Li Tian,*, Rajkumar Kadaba,*, Sun-Ah You,*, Mugen Liu*, Ayse Anil Timur, Lin Yang, Qiuyun Chen, Przemyslaw Szafranski, Shaoqi Rao, Ling Wu, David E. Housman, Paul E. DiCorleto, David J. Driscol, Julian Borrow and Qing Wang. 2004.Positional cloning of an angiogenic factor gene: VG5Q mutations cause susceptibility to Klippel-Trenaunay syndrome; Nature 427(6975):640-5(*并列第一作者, IF 36.28)

15. Fan C, Liu M, Wang Q. 2003. Functional analysis of TBX5 missense mutations associated with Holt-Oram syndrome. J Biol Chem. 278(10): 8780-5(IF 4.773).

Courses Taught

Genetics

Project

NSFC: 31071106,81270983,81371064,31471194,31571303,81670980

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