Professor

Phone: 159-2746-0122

Email: wangchenhui@hust.edu.cn

Academic Areas: Immunology

Research Interests: My lab is to try to understand the molecular mechanism of many autoimmune diseases, such as inflammatory bowel diseases, multiple sclerosis, type I diabetes, rheumatoid arthritis et al, and try to find new signaling or targets involved in the diseases.

Academic Degrees

Ph.D

Professional Experience

Oct. 2011-Aug. 2014   postdoctoral fellow    Cleveland Clinic

Aug.2014-Sep. 2015   Research associate     Cleveland Clinic

Sep. 2015-now        Professor     Huazhong University of Science & Technology

Selected Publications

1. Chenhui Wang*, Ling Wu*, Katarzyna Bulek. et al. The psoriasis-associated D10N variant of the adaptor Act1 with impaired regulation by the molecular chaperone hsp90. Nature Immunology, 2013, 14 (1) 72-81. ARTICLE OF THE MONTH of January 2013 in Nature Immunology.

2. Bradley N. Martin*, Chenhui Wang*, Cun-jin Zhang. et al. T cell-intrinsic ASC critically promotes TH17-mediated experimental autoimmune encephalomyelitis. Nature Immunology. 2016 May; 17(5): 583-92. (co-first author).

3. Chenhui Wang*, Bradley N. Martin*, Cunjin Zhang1, Katarzyna Bulek, Zizhen Kang, Xin Chen, Tomasz Herjan, Wen Qian, Junjie Zhao and Xiaoxia Li. IL-17 induced NOTCH activation in NG2+ glial cells plays an important role in the pathogenesis of autoimmune encephalomyelitis. In revision.

4. Bradley N. Martin*, Chenhui Wang*, Tomasz Herjan, Jami Willette-Brown, Muhammet F. Gulen, Hao Zhou, Katarzyna Bulek, Junjie Zhao, Luigi Franchi, Takashi Sato, Goutham Narla, Xiao-Ping Zhong, Dennis Klinman, Katherine A. Fitzgerald, Michael Karin, Gabriel Nuñez, George Dubyak, Yinling Hu*, and Xiaoxia Li*. IKKα negatively regulates ASC-dependent inflammasome activation. Nature Communications. 2014 Sep 30;5:4977 (co-first author)

5. Ling Wu*, Chenhui Wang*, Bertrand Boisson, Saurav Misra, Pat Rayman, James H. Finke, Anne Puel, Jean-Laurent Casanova*, Xiaoxia Li*. The differential regulation of human ACT1 isoforms by Hsp90 in IL-17 signaling. J Immunol. 2014 Jul 14. pii: 1400715. [Epub ahead of print] (co-first author)

6. Zizhen Kang, Chenhui Wang, Jarod Zepp, Ling Wu, Kevin Sun, Junjie Zhao, Unni Chandrasekharan, Paul E. DiCorleto, Bruce D. Trapp,Richard M. Ransohoff, Li X.  Experimental autoimmune encephalomyelitis: The NG2+ glial cell response to interleukin (IL)-17/Act1 signaling mediates the role of IL-17 in disease pathogenesis. Nature Neuroscience. 2013 Oct;16(10):1401-8.

7. Bertrand Boisson*, Chenhui Wang, Vincent Pedergnana, Ling Wu, Sophie Cypowyj, Michel Rybojad , Aziz Belkadi, Capucine Picard, Laurent Abel, Claire Fieschi, Anne Puel*, Xiaoxia Li* and Jean-LaurentCasanova*. A biallelic mutation of ACT1 that selectively abolishes IL-17 responses in humans with chronic mucocutaneous candidiasis. Immunity 2013 Oct 17;39(4):676-86.

8. Kang Z, Swaidani S, Yin W, Wang C, Barlow JL, Gulen MF, Bulek K, Do JS, Aronica M, McKenzie AN, Min B, Li X. Epithelial cell-specific Act1 adaptor mediates interleukin-25-dependent helminth expulsion through expansion of Lin(-)c-Kit(+) innate cell population. Immunity. 2012 May 25;36(5):821-33.

9. Hui-Yan Li*, Hui Liu*, Chen-Hui Wang, Ji-Yan Zhang, Jiang-Hong Man, Yan-Fei Gao, Pei-Jing Zhang,Wei-Hua Li, Jie Zhao, Xin Pan, Tao Zhou, Wei-Li Gong, Ai-Ling Li & Xue-Min Zhang. Deactivation of the kinase IKK by CUEDC2 through recruitment of the phosphatase PP1. Nature Immunology, 2008, 9(5): 533-541.

10. Kang Z, Liu L, Spangler R, Spear C, Wang C, Gulen MF, Veenstra M, Ouyang W, Ransohoff RM, Li X. IL-17-induced Act1-mediated signaling is critical for cuprizone-induced demyelination. J Neurosci. 2012 Jun 13;32(24):8284-92.

11. Lin Gong*, Chen-Hui Wang*, Yi Jiao Huang, Feng Liu, Teng Li, Jiang Dai, Ai ling Li, Tao Zhou, Qing Xia, Liang Chen. CUEDC2 interacts with Heat Shock Protein 70 and negatively regulates its chaperone activity. Biochem Biophys Res Commun. 2014 Apr 25; 447(1):64-9. (co-first author)

12. Liu C, Swaidani S, Qian W, Kang Z, Sun P, Han Y, Wang C, Gulen MF, Yin W, Zhang C, Fox PL, Aronica M, Hamilton TA, Misra S, Deng J, Li X. A CC' loop decoy peptide blocks the interaction between Act1 and IL-17RA to attenuate IL-17- and IL-25-induced inflammation. Sci Signal. 2011 Nov 1; 4(197):ra72.

13. H-Y Zhang*, J-H Man*, B Liang, T Zhou, C-H Wang, T Li, H-Y Li, W-H  Li, B-F Jin,P-J Zhang, J Zhao, X Pan, K He, W-L Gong, X-M Zhang and A-L Li. Tumor-targeted delivery of biologically active TRAIL protein. Cancer Gene Therapy. 2010, 17: 334-343.

14. Tao Zhou*, Bing Liang*, Gui-Ying Su, Wei-Li Gong, Hui-Yan Li, Li-Feng Tian, Kun He, Jie Zhao, Jiang-Hong Man,Tao Li,Wei-Hua Li, Zhi-Yi Zhang, Chen-Hui Wang, Ai-Ling Li, Hui Liu, Xin Pan, Pei-Jing Zhang, Bao-Feng Jin and Xue-Min Zhang. Identification of ubiquitin target proteins using cell-based arrays. Journal of Proteomics Research,2007,6(11): 4397-406.

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