Professor and Dean

Phone: (027) 8779-3502

Email: qkwang@hust.edu.cn

Academic Areas: Genetics, Biochemistry and Molecular Biology, Biophysics, Molecular Cardiology

Research Interests: Genetic and molecular basis of cardiovascular diseases and Mendelian disorders; Genomics; Ion channels; Vascular biology; Signal transduction; Autophagy; Targeted therapy

Academic Degrees

B.S.  (August, 1980 to July, 1984)

Major in genetics and plant breeding,

Gansu University of Agricultural Sciences, P. R. China

 

Ph.D. (July, 1986 to January, 1993)

Major in genetics and development 

Cornell University (with Dr. Joseph M. Calvo)

 

M.B.A. (January, 2000 to May, 2002)

Major in business administration

Cleveland State University

Professional Experience

Postdoctoral Fellow

December, 1992-April, 1993, Section of Biochemistry, Molecular and Cell Biology, Cornell University (with Dr. Joseph M. Calvo)

 

Postdoctoral Fellow

April, 1993-November, 1994, Department of Human Genetics, University of Utah (with Dr. Mark T. Keating)

 

Associate

1994- 1996, Howard Hughes Medical Institute, University of Utah (with Dr. Mark T. Keating)

 

Assistant Professor (tenure-track)

April, 1996-April, 1999, Department of Pediatrics (Cardiology)

Baylor College of Medicine

 

Assistant Staff

March, 1999-February, 2003, Center for Molecular Genetics, Department of Molecular Cardiology, Lerner Research Institute, Department of Cardiovascular Medicine, Cleveland Clinic Foundation

 

Associate Staff

2003- 2004, Center for Molecular Genetics, Department of Molecular Cardiology, Lerner Research Institute, Center for Cardiovascular Genetics, Department of Cardiovascular Medicine, Cleveland Clinic

 

Full Staff  

July, 2004-2008, Center for Molecular Genetics, Department of Molecular Cardiology, Lerner Research Institute, Center for Cardiovascular Genetics, Department of Cardiovascular Medicine, the Cleveland Clinic

 

2006-present, Yangtze Scholar Distinguished Visiting Professor, the Ministry of Education, China,

 

2007-present, Director, Key Laboratory of Molecular Biophysics of the Ministry of Education, Huazhong University of Science and Technology, Wuhan, China

 

Professor and Dean

2008-present

College of Life Science and Technology, Huazhong University of Science and Technology

Selected Publications

1. Lu Q, Yao Y, Hu Z, Hu C, Song Q, Ye J, Xu C, Wang AZ, Chen Q, Wang QK. (2016) Angiogenic Factor AGGF1 Activates Autophagy with an Essential Role in Therapeutic Angiogenesis for Heart Disease. PLoS Biol. 14(8):e1002529.

2. Zhang T, Yao Y, Wang J, Li Y, He P, Pasupuleti V, Hu Z, Jia X, Song Q, Tian X, Hu C, Chen Q, Wang QK. (2016) Haploinsufficiency of Klippel-Trenaunay syndrome gene Aggf1 inhibits developmental and pathological angiogenesis by inactivating PI3K and AKT and disrupts vascular integrity by activating VE-cadherin. Hum Mol Genet. 2016 Aug 13. pii: ddw273. [Epub ahead of print]

3. Huang Y, Wang Z, Liu Y, Xiong H, Zhao Y, Wu L, Yuan C, Wang L, Hou Y, Yu G, Huang Z, Xu C, Chen Q*, Wang QK*. (2016) αB-Crystallin interacts with Nav1.5 and regulates ubiquitination and internalization of cell surface Nav1.5. J Biol Chem. 291:11030-41.

4. Huang Y, Wang C, Yao Y, Zuo X, Chen S, Xu C, Zhang H, Lu Q, Chang L, Wang F, Wang P, Hu Z, Song Q, Yang X, Li C, Li S, Zhao Y, Yang Q, Yin D, Wang X, Si W, Li X, Xiong X, Wang D, Huang Y, Luo C, Li J, Wang J, Chen J, Wang L, Wang L, Han M, Ya J, Chen F, Liu J, Liu Y, Wu G, Yang B, Cheng X, Liao Y, Wu Y, Ke T, Chen Q, Elston R, Rao S, Yang Y*, Xia Y, and Wang QK*. (2015) Molecular basis of gene-gene interaction: cyclic cross-regulation of gene expression and post-GWAS gene-gene interaction involved in atrial fibrillation. PLoS Genet 11(8): e1005393.

5. Zhang X, Bogunovic D, Payelle-Brogard B, Francois-Newton V, Speer SD, Yuan C, Volpi S, Li Z, Sanal O, Mansouri D, Tezcan I, Rice GI, Chen C, Mansouri N, Mahdaviani SA, Itan Y, Boisson B, Okada S, Zeng L, Wang X, Jiang H, Liu W, Han T, Liu D, Ma T, Wang B, Liu M, Liu JY, Wang QK, Yalnizoglu D, Radoshevich L, Uzé G, Gros P, Rozenberg F, Zhang SY, Jouanguy E, Bustamante J, García-Sastre A, Abel L, Lebon P, Notarangelo LD, Crow YJ, Boisson-Dupuis S*, Casanova JL*, Pellegrini S*. (2015) Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation. Nature. 517:89-93.

6. Li L, Chen D, Li J, Wang X, Wang N, Xu C and Wang QK*. (2014) Aggf1 acts at the top of the genetic regulatory hierarchy in specification of hemangioblasts in zebrafish. Blood 2014 123: 501-508.

7. Xu C, Yang Q, Xiong H, Wang L, Cai J, Wang F, Li S, Chen J, Wang C, Wang D, Xiong X, Wang P, Zhao Y, Wang X, Huang Y, Chen S, Yin D, Li X, Liu Y, Liu J, Wang J, Li H, Ke T, Ren X, Wu Y, Wu G, Wan J, Zhang R, Wu T, Wang J, Xia Y, Yang Y, Cheng X, Liao Y, Chen Q, Zhou Y, He Q, Tu X*, Wang QK*. (2014) Candidate pathway-based genome-wide association studies identify novel associations of genomic variants in the complement system associated with coronary artery disease. Circ Cardiovasc Genet. 7:887-94.  [Editorial by Andersson C and Vasan RS. Compiling the complement of genes implicated in coronary artery disease. Circ Cardiovasc Genet. 2014;7:738-40.]

8. Bai Y, Nie S, Jiang G, Zhou Y, Zhou M, Zhao Y, Li S, Wang F, Lv Q, Huang Y, Yang Q, Li Q, Li Y, Xia Y, Liu Y, Liu J, Qian J, Li B, Wu G, Wu Y, Wang B, Cheng X, Yang Y, Ke T, Li H, Ren X, Ma X, Liao Y, Xu C, Tu X*, Wang QK*. (2014) Regulation of CARD8 Expression by ANRIL and Association of CARD8 SNP rs2043211 (p.C10X) with Ischemic Stroke.  Stroke 45(2):383-8.

9. Tu X, Nie S, Liao Y, Zhang H, Fan Q, Xu C, Bai Y, Wang F, Ren X, Tang T, Xia N, Li S, Huang Y, Liu J, Yang Q, Zhao Y, Lv Q, Li Q, Li Y, Xia Y, Qian J, Li B, Wu G, Wu Y, Yang Y, Wang QK*, Cheng X*.  (2013) The IL-33-ST2L pathway is associated with coronary artery disease in a Chinese Han population. Am J Hum Genet. 93:652-60. (PMID 24075188  PMCID: PMC 379127)

10. Chen D, Li L, Tu X, Yin Z, Wang Q. (2013) Functional characterization of Klippel-Trenaunay syndrome gene AGGF1 identifies a novel angiogenic signaling pathway for specification of vein differentiation and angiogenesis during embryogenesis.  Hum Mol Genet. 22(5):963-76.

11. Wang C, Li Y, Shi L, Ren J, Patti M, Wang T, de Oliveira JR, Sobrido MJ, Quintáns B, Baquero M, Cui X, Zhang XY, Wang L, Xu H, Wang J, Yao J, Dai X, Liu J, Zhang L, Ma H, Gao Y, Ma X, Feng S, Liu M, Wang QK, Forster IC, Zhang X, Liu JY. (2012) Mutations in SLC20A2 link familial idiopathic basal ganglia calcification with phosphate homeostasis. Nat Genet. 44:254-6.

12. Wang F, Xu C, He Q, Cai J, Li X, Wang D, Xiong X, Liao Y, Zeng Q, Yang Y, Cheng X, Li Cm Yang R, Wang C, Wu G, Lu Q, Bai Y, Huang Y, Yin D, Yang Q, Wang X, Dai D, Zhang R, Wan J, Ran J, Li S, Zhao Y, Fu F, Huang Y, Li Q, Shi S, Lin N, Pan Z, Li Y, Yu B, Wu Y, Ke Y, Lei J, Wang N, Luo C, Ji L, Gao L, Li L, Liu H, Huang E, Cui J, Jia N, Ren X, Li H, Ke T, Zhang X, Liu J, Liu M, Xia H, Yang B, Shi L, Xia Y, Tu X*, and Wang QK*. (2011) Genome-wide association identifies a susceptibility locus for coronary artery disease in the Chinese Han population. Nature Genetics 2011;43:345-349. [cover article of the issue]

13. Xu C, Wang F, Wang B, Li X, Li C, Wang D, Xiong X, Wang P, Lu Q, Wang X, Yang Q, Yin D, Huang Y, Ji L, Wang N, Chen S, Cheng X, Liano Y, Ma X, Su D, Chen G, Xia H, Shi, Tu X,* and Wang QK.* (2010) Minor allele C of chromosome 1p32 SNP rs11206510 confers risk of ischemic stroke in the Chinese Han population.  Stroke 41(8):1587-92.

14. Zhang X, Chen S, Yoo S, Chakravarti S, Zhang T, Ke T, Oberti C, Yong SL, Fang F, Li L, de la Fuente R, Wang L, Chen Q, and Wang QK*. (2008) Mutation in nuclear pore component NUP155 leads to atrial fibrillation and early sudden cardiac death.  Cell 135:1017-1027.

15. Shen G, Li L, Girelli D, Seidelmann SB, Rao S, Fan C, Park JE, Xi Q, Li J, Hu Y, Olivieri O, Marchant K, Barnard J, Corrocher R, Elston R, Cassano J, Henderson S, Hazen SL, Plow EF, Topol EJ, and Wang QK (2007) An LRP8 variant is associated with familial and premature CAD and MI.  Am J Hum Genet 81:780-791.

16. Du W, Bautista JF, Yang H, Diez-Sampedro A, You S, Wang L, Kotagal P, Luder HO, Shi J, Cui J, Richardson GB, and Wang QK*. (2005) Calcium-sensitive potassium channelopathy in human epilepsy and paroxysmal movement disorder. Nature Genetics 37:733-738. [Editorial by Lancet Neurology, V. Chen Channelopathy linked to epilepsy and paroxysmal dyskinesia. 2005; 4:462]

17. Tian, X., Yong, S., Wan, X., Wu, L., Chung, M. K., Tchou, P. J., Rosenbaum, D. S., van Wagoner, D. R., Kirsch, G. E., and Wang, Q. (2004) Mechanisms by which SCN5A mutation N1325S causes cardiac arrhythmias and sudden death in vivo. Cardiovascular Research, 61, 256-267. [accompanied by an Editorial by Dr. Carlo Napolitano, Transgenic models in cardiac arrhythmias: how close can we get to the bedside? Cardiovascular Research 2004; 61:206-207]

18. Tian, X.L., Kadaba, R., You, S.A., Liu, M., Timur, A.A., Yang, L., Chen, Q., Szafranski, P., Rao, S., Wu, L., Housman, D.E., DiCorleto, P.E., Driscoll, D.J., Borrow, J., and Wang, Q.* (2004) Identification of an angiogenic factor that when mutated causes susceptibility to Klippel Trenaunay syndrome.  Nature, 427; 640-645. [Highlighted by Nature in a news and views article by Lambrechts D and Carmeliet P (2004) Genetic spotlight on a blood defect. 427: 592-594]

19. Oberti, C., Wang, L., Li, L., Dong, J., Rao, S., Du, W., and Wang, Q.  (2004) Genome-Wide Linkage Scan Identifies a Novel Genetic Locus on Chromosome 5p13 for Neonatal Atrial Fibrillation Associated with Sudden Death and Variable Cardiomyopathy. Circulation 110:3753-3759.

20. Wang, Q., Rao, S., Shen, G., Li, L., Moliterno, D. J., Newsby, L. K., Rogers, W. J., Cannata, R., Zirzow, E., Elston, R. C., and Topol, E. J. (2004) Premature myocardial infarction novel susceptibility locus on chromosome 1p34-36 identified by genome-wide linkage analysis. American Journal of Human Genetics, 74: 262-271.  [Highlighted in the March 2004 issue of Nature Genetics]

21. Chen, S., Ondo, W.G., Rao, S., Li, L., Chen, Q., and Wang, Q. (2004) Genome-wide linkage scan identifies a novel susceptibility locus for restless legs syndrome on chromosome 9p.  American Journal of Human Genetics, 74:876-885.

22. Chen, Q., Kirsch, G., Zhang, D., Brugada, R., Brugada, J., Brugada, P., Potenza, D., Moya, A., Borggrefe, M., Breithardt, G., Oritz-Lopez, R., Wang, Z., Anzalevitch, C., O’Brien, R. E., Schultz-Bahr, E., Keating, M. T., Towbin, J. A., and Wang, Q*. (1998) Genetic basis and molecular mechanism for idiopathic ventricular fibrillation. Nature 392, 293-296.

23. Schulze-Bahr*, E., Wang, Q.*, Wedekind, H., Haverkamp, W., Chen, Q., Sun, Y., Rubie, C., Hordt, M., Towbin, J. A., Borggrefe, M., Assmann, G., Qu, X., Somberg, J., Breithardt, G., Oberti, C., and Funke, H. (1997) KCNE1 mutations cause Jervell and Lange-Nielsen syndrome. Nature Genetics 17, 267-268. [*co-first author].

24. Wang, Q., Curran, M. E., Splawski, I., Connors, T. D., Burn, T. C., Millholland, VanRaay, T. J., Shen, J., de Jager, T., Schwartz, P. J., Towbin, J. A., Moss, A. J., Atkinson, D. L., Timothy, K. W., Vincent, G. M., Landes, G. M., and Keating, M. T*. (1996)  Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias.  Nature Genetics 12, 17-23. [Highlighted by an Editorial by the Editor-in-Chief]

25. Wang, Q., Shen, J., Splawski, I., Atkinson, D., Li, Z., Robinson, J. L., Moss, A. J., Towbin, J. A., and Keating, M. T*. (1995) SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome. Cell 80, 805-811.

Courses Taught

Genomics (undergraduate course)

Advances in Biological Sciences (M.S. course)

Advances in Genetics (Ph.D. course)

Project

Center for Human Genome Research

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