Professor

Phone: 00

Email: xinjunzhang@hust.edu.cn

Academic Areas: Biochemistry and Cell Biology

Research Interests: Cancer and Metabolic disease and related signaling pathways

Academic Degrees

Ph.D. in Biology, 2006, Tsinghua University, Beijing, China;

B.S., 2000, Peking University, Beijing, China. 

Professional Experience

Professor (2016 - present), College of Life Science and Technology, HUST

Instructor (2012 - 2016), Harvard Medical School, USA

Postdoctoral Research Fellow (2006 – 2012), Harvard Medical School, USA

Selected Publications

  1. Zhang X, He X. Methods for Studying Wnt Protein Modifications/Inactivations by Extracellular Enzymes, Tiki and Notum. Methods Mol Biol. 2016; 1481: 29-38.
  2. Zhang X, Macdonald BT, Gao H, Shamashkin M, Coyle AJ, Martinez RV, He X. Characterization of Tiki, a New Family of Wnt-specific Metalloproteases. J Biol Chem. 2016 Jan 29; 291(5): 2435-43.
  3. Zhang X, Cheong SM, Amado NG, Reis AH, MacDonald BT, Zebisch M, Jones EY, Abreu JG, Xi He. Notum is required for neural and head induction via Wnt deacylation, oxidation and inactivation. Dev Cell. 2015 Mar 23; 32(6): 719-30.
  4. MacDonald BT, Hien A, Zhang X, Iranloye O, Virshup DM, Waterman ML, He X. Disulfide Bond Requirements for Active Wnt Ligands. J Biol Chem. 2014 Jun 27;289(26):18122-36.
  5. Zhang X, He X. PAF Makes It EZ(H2) for β-Catenin Transactivation. Mol Cell. 2013 Oct 24; 52(2):157-8. Preview.
  6. Kim SE, Huang H, Zhao M, Zhang X, Zhang A, Semonov MV, MacDonald BT, Zhang X, Garcia Abreu J, Peng L, He X. Wnt stabilization of b-catenin reveals principles for morphogen receptor-scaffold assemblies. Science. 2013 May 17; 340(6134): 867-70.
  7. Zhang X, Abreu JG, Yokota C, Macdonald BT, Singh S, Coburn KL, Cheong SM, Zhang MM, Ye QZ, Hang HC, Steen H, He X. Tiki1 is required for head formation via Wnt cleavage-oxidation and inactivation. Cell. 2012 Jun 22; 149(7): 1565-77.
  8. Semënov MV, Zhang X, He X. DKK1 antagonizes Wnt signaling without promotion of LRP6 internalization and degradation. J Biol Chem. 2008 Aug 1; 283(31): 21427-32.
  9. Zeng X, Huang H, Tamai K, Zhang X, Harada, Y, Wang J, Doble B, Woodgett J, Wynshaw-Boris A, Hsieh J-C, He X. Initiation of Wnt signaling: Control of Wnt coreceptor LRP6 phosphorylation/activation via Frizzled/Dishevelled/Axin Functions. Development.  2008, 135(2):367-75.
  10. Wang F, Zhang H, Zhang X, Wang Y, Ren F, Zhang X, Zhai Y, Chang Z. Varp interacts with Rab38 and functions as its potential effector. Biochem Biophys Res Commun. 2008 Jul 18; 372(1):162-7.
  11. Ren Y, Cheng L, Rong Z, Li Z, Li Y, Zhang X, Xiong S, Hu J, Fu XY, Chang Z. hSef potentiates EGF-mediated MAPK signaling through affecting EGFR trafficking and degradation. Cell Signal. 2008 Mar; 20(3):518-33.
  12. Zhang X, He X, Fu X-Y, Chang Z. Varp is a Rab21 guanine nucleotide exchange factor and regulates endosome dynamics. J Cell Sci. 2006; 119, 1053-1062.
  13. Tamai K, Zeng X, Liu C, Zhang X, Harada Y, Chang Z, He X. A mechanism for Wnt coreceptor activation. Mol Cell. 2004, 13(1): 149-56.
  14. Li L, Xin H, Xu X, Huang M, Zhang X, Chen Y, Zhang S, Fu X-Y, Chang Z. CHIP mediates degradation of Smad proteins and potentially regulates Smad-induced transcription. Mol Cell Biol. 2004, 24(2):856-64.

Project

Biochemistry and Molecular Biology

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