Associate Professor

Phone: 86-27-87793053

Email: shengwang@hust.edu.cn

Academic Areas: Structural and Computational Biology

Research Interests: Structure and functions of macromolecules related to human diseases by X-ray, NMR, etc; Rational drug design and virtual screening; Molecular interaction by Computational biology

Academic Degrees

PhD in Biomedical Engineering, 2004, Chongqing University, Chongqing, China;

MS in Physical Chemistry, 2000, Fujian Institute of Research on the Structure Chinese Academy of Sciences, Fujian, Chian;

BS in Environmental Chemistry, 1997, Southwest Normal University, Chongqing, China

Professional Experience

Associate Professor (2007-present); School of Life Science and Technology, HUST

Lecture (2006-2007); School of Life Science and Technology, HUST

Selected Publications

1. Chun Zhang,* Zhen Wang, Liangxiao Tan, Tian-Long Zhai, Sheng Wang,* Bien Tan,* Yan-Song Zheng,* Xiang-Liang Yang, and Hui-Bi Xu. A Porous Tricyclooxacalixarene Cage Based on Tetraphenylethylene.  Angew Chem Int Ed, 54, 2015: 9244 –9248.

2. Tianfu Cai,Ji Luo, Er Meng, Jiuping Ding, Songping Liang, Sheng Wang, Zhonghua Liu. Mapping the interaction site for the tarantula toxin hainantoxin-IV (b-TRTX-Hn2a) in the voltage sensor module of domain II of voltage-gated sodium channels, Peptides, 68, 2015: 148–156.

3. Pan Li, Haowen Liu, Chaohua Lai, Peibei Sun, Wenping Zeng, Fangming Wu, Longhua Zhang, Sheng Wang*, Changlin Tian & Jiuping Ding. Differential Modulations of KCNQ1 by Auxiliary Proteins KCNE1 and KCNE2, Scientific Reports. 4, 2014:4973

4. HaoWen Liu, PanPan Hou, XiYing Guo, ZhiWen Zhao, Bin Hu, Xia Li, LuYang Wang, JiuPing Ding, and Sheng Wang*. Structural Basis for Calcium and Magnesium Regulation of a Large Conductance Calcium-activated Potassium Channel with β1 Subunits, J Biol, Chem, 289, 2014: 16914-16923.

5. Panpan Hou, Wenping Zeng, Geliang Gan, Caixia Lv, Xiying Guo, Zheng Zhang, Haowen Liu, Ying Wu, Jing Yao, Aguan D. Wei, Sheng Wang*, Jiuping Ding. Inter-α/β subunits coupling mediating pre-inactivation and augmented activation of BKCa(β2) Scientific Reports, 3, 2013: 1666.

6.  Ying Wu,Yu Xiong, Sheng Wang,Hong Yi, Hui Li, Na Pan, Frank T. Horrigan, Yingliang Wu and Jiuping Ding. Intersubunit Coupling in the Pore of BK Channels. J Biol Chem, 284, 2009: 23353-23363.

7. Sheng Wang,* Xiang Lin, Ying Wan, Wenbin Yang, Shengmin Zhang, Canzhong Lu, and Honghui Zhuang. A Large, Bowl-Shaped {Mo51V9} Polyoxometalate, Angew Chem Int Ed, 46, 2007: 3490–3493.

Courses Taught

0703384: Molecular Design for Pharmaceutical

0702241: Structural Biology

0707281: Experiments in Structural Biology

 

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