Professor

Phone: 00

Email: hexj@hust.edu.cn

Academic Areas: Biophysics

Research Interests: During development of the nervous system, axons are guided to their proper targets by sensing a variety of extracellular cues in the local environment. The signal finally selectively alters the stability of the actin cytoskeleton and microtubules

Academic Degrees

Ph.D. in Biochemistry and molecular biology

Professional Experience

Sep2005~Oct 2008    Research Assistant

Institute of Biophysics, CAS, Beijing

Sep2008 ~Feb 2014   Postdoctoral Researcher  & Assistant Instructor

UT Southwestern Medical Center, US

Feb 2014~PRESENT         Professor; Principal Investigator

School of Life Science and Technology,

Huazhong University of Science and Technology, Wuhan,China

Selected Publications

  1. He S, Zhao J, Song S, He X, Minassian A, Zhou Y, Zhang J, Brulois K, Wang Y, Cabo J, Zandi E, Liang C, Jung J, Zhang X, and Feng P* Viral Pseudo Enzymes Activate RIG-I via Deamidation to Evade   Cytokine Production.  Mol Cell. 2015 ;58(1): 134–146.
  2. Xu H, He X, Zheng H, Huang LJ, Hou F, Yu Z, Cruz MJ, Borkowski B, Zhang X*, Chen ZJ*, Jiang QX* Structural basis for the prion-like MAVS filaments in antiviral innate immunity, Elife, 3:e01489, 2014
  3. He X, Kuo YC, Rosche TJ, Zhang X* Structural basis for autoinhibition of the guanine nucleotide exchange factor FARP2, Structure, 21(3):355-64, 2013
  4. Yuan P, Bartlam M, Lou Z, Chen S, Zhou J, He X, Lv Z, Ge R, Li X, Deng T, Fodor E, Rao Z, Liu Y. Crystal structure of an avian influenza polymerase PA(N) reveals an endonuclease active site. Nature. 2009 Apr 16;458(7240):909-13.
  5. He X, Zhou J, Bartlam M, Zhang R, Ma J, Lou Z, Li X, Li J, Joachimiak A, Zeng Z, Ge R, Rao Z, Liu Y. Crystal structure of PAc: PB1N complex from bird flu H5N1. Nature. 2008 Aug 28;454(7208):1123-6.
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