Professor

Phone: 0086-27-87792031

Email: jfliu@mail.hust.edu.cn

Academic Areas: Biophysics, biochemistry, neuroscience and pharmacology.

Research Interests: Structure and function of GPCR, neuron activity and signal transduction, longevity and aging in C. elegans.

Academic Degrees

1994 –1999          Ph.D. Molecular and Cell Biology, Lab of CRRET (CNRS UPRESA 7053), University of Paris XII, Paris, France.

1993 –1994          M.S. Biochemistry and Biotechnology, Lab of Molecular and Cellular Oncology, University of Paris XIII, Paris, France.

1989 –1993          B.S. Biochemistry, Department of Biochemistry, Wuhan University, Wuhan, China.

Professional Experience

2002 - present    Professor, College of Life Science and Technology, HuaZhong University of Science and technology, Wuhan, China.

2001 - 2002         Staff Scientist in Aventis Pharma, Bridgewater, New Jersey, USA.

1999 - 2001          Post-doc Fellow in Institut Cochin Génétique Moléculaire (ICGM), Paris, France.

1994 - 1999          Research Assistant in the Laboratoire de Recherche sur la Croissance Cellulaire, la Réparation et la Régénération Tissulaire (CRRET) University of Paris XII, Creteil, France.

1993 - 1994          Research Assistant in Institut d’oncologie Cellulaire et Moléculaire Humaine (I.O.C.M.H), University of Paris XIII, Bobigny, France.

Selected Publications

  1. Gong J, Yuan Y, Ward A, Kang L, Zhang B, Wu Z, Peng J, Feng Z, *Liu J, *Xu XZ.  The C. elegans taste receptor homolog LITE-1 is a photoreceptor. Cell. ,2016,167(5):1252-1263.
  2. Li G, Gong J, Lei H, *Liu J, *Xu XZ.  Promotion of behavior and neuronal function by reactive oxygen species in C. elegans. Nature Communications. ,2016,7:13234.
  3. Chun L, Gong J, Yuan F, Zhang B, Liu H, Zheng T, Yu T, *Xu XZ, *Liu J.  Metabotropic GABA signalling modulates longevity in C. elegans. Nature Communications.,2015, 6: 8828.    
  4. Xue L, Rovira X, Scholler P, Zhao H, *Liu J, *Pin JP, Rondard P. Major ligand-induced rearrangement of the heptahelical domain interface in a G protein-coupled receptor dimer. Nature Chemical Biology.,2015, 11(2):134-40.
  5. Xu F, Zhao H, Feng X, Chen L, Chen D, Zhang Y, *Nan F, *Liu J, *Liu BF. Single-Cell Chemical Proteomics with an Activity-Based Probe: Identification of Low-Copy Membrane Proteins on Primary Neurons. Angew Chem Int Ed Engl. ,2014,53(26):6730-3.

The other papers within the past three years:

  1. Sun B, Chen L, Liu L, Xia Z, Pin JP, *Nan F, *Liu J.  A negative allosteric modulator modulates GABAB-receptor signalling through GB2 subunits. Biochem J. ,2016,473(6):779-87.
  2. Wang X, Li G, Liu J, Liu J, *Xu XZ. TMC-1 Mediates Alkaline Sensation in C. elegans through Nociceptive Neurons. Neuron. ,2016,91(1):146-54.
  3. Cao Q, *Han X, Chun L, Liu J, Li L.  Note: Magnetic targeting for enhancement of the activation efficiency of G protein-coupled receptor with a two-pair coil system. Rev Sci Instrum., 2016,87(1):016103.
  4. Chaudhuri J, Bose N, Gong J, Hall D, Rifkind A, Bhaumik D, Peiris TH, Chamoli M, Le CH, Liu J, Lithgow GJ, Ramanathan A, Xu XZ, Kapahi P. A Caenorhabditis elegans Model Elucidates a Conserved Role for TRPA1-Nrf Signaling in Reactive α-Dicarbonyl Detoxification. Curr Biol., 2016,26(22):3014-25.
  5. Li LB, Lei H, Arey RN, Li P, Liu J, Murphy CT, *Xu XZ, *Shen K. The Neuronal Kinesin UNC-104/KIF1A Is a Key Regulator of Synaptic Aging and Insulin Signaling-Regulated Memory. Curr Biol., 2016,26(5):605-15.
  6. Zhang B, Ronan E, Xiao R, *Liu J, *Xu XZ. Environmental temperature differentially modulates C. elegans longevity through a thermosensitive channel. Cell Reports., 2015,11(9):1414-24.
  7. Zhang Z, Zhang W, *Huang S, Sun Q, Wang Y, Hu Y, Sun N, Zhang Y, Jiang Z, Minato N, Pin JP, *Su L, *Liu J. GABAB receptor promotes its own surface expression by recruiting a Rap1-dependent signaling cascade. J Cell Sci., 2015,128(12):2302-13.
  8. Zhang W, *Xu C, Tu H, Wang Y, Sun Q, Hu P, Hu Y, Rondard P, *Liu J. GABAB receptor upregulates fragile X mental retardation protein expression in neurons. Sci Rep., 2015,5:10468.
  9. Wan M, Zhang W, Tian Y, Xu C, Xu T, *Liu J, *Zhang R. Unraveling a molecular determinant for clathrin-independent internalization of the M2 muscarinic acetylcholine receptor. Sci Rep., 2015,5:11408.
  10. Chen L , Sun B , Zhang Y, Xu T , Xia Z , *Liu J, *Nan F. Discovery of a Negative Allosteric Modulator of GABAB Receptors. ACS Med. Chem. Lett., 2014,5(7):742-7.
  11. Xu C, Zhang W, Rondard P, Pin JP, *Liu J. Complex GABAB receptor complexes: how to generate multiple functionally distinct units from a single receptor. Front Pharmacol. ,2014,5:12.
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