Lecture

Phone: 86-027-87792024

Email: lchun@hust.edu.cn

Academic Areas: Molecular Genetics

Research Interests: GPCR and aging, longevity and metabolism

Academic Degrees

2000.09 –2005.07     Ph.D. Genetics, Institute of Genetics and Developmental Biology, Chinese Academy of Science, Beijing, China

                                          Ph.D Thesis: Bioactivity and Structure-Function Relationship of Recombinant Human Secondary Lymphoid Tissue Chemokine (SLC)

1996.09 –2000.07      B.S. Biology, College of Life Science, Beijing Normal University, Beijing, China

Professional Experience

2016.1 –present     Lecture, College of Life Science and Technology, Huazhong University of Science and technology, 1037 Luoyu Road, Wuhan, China.

2008.7 –2015.12    Post-doc Fellow, College of Life Science and Technology, Huazhong University of Science and technology, 1037 Luoyu Road, Wuhan, China

Project Title 1: Lipid Rafts Regulating GABAB Receptor Lateral Diffusion via a Palmitoylation-Dependent Mechanism

Project Title 2: Metabotropic GABA signaling modulates longevity in C.elegans

2005.9 – 2008.6  Project Manager, Beijing Sinodev Bioengineering Co. Ltd., 15 Datun Road, Beijing, China.

Responsible for conducting preclinical research on a novel anticancer monoclonal antiboy

Selected Publications

SCIENTIFIC PUBLICATIONS: ( corresponding author; *co-first authors)

1. Chun L., Gong J., Yuan F., Zhang B., Liu H., Zheng T., Yu T., Xu XZ. & Liu J. (2015) Metabotropic GABA signaling modulates longevity in C.elegans. Nature Communications 6, 8828

2. Xiao R., Chun L., Ronan EA., Friedman DI., Liu J. & Xu XZ. (2015) RNAi interrogation of dietary modulation of development, metabolism, behavior, and aging in c. elegans. Cell Reports 11, 1123-33

3. *Baloucoune GA., *Chun L., *Zhang W., Xu C., Huang S., Sun Q., Wang Y., Tu H. & Liu J. (2012) GABAB Receptor subunit GB1 at the cell surface independently activates ERK1/2 through IGF-1R transactivation. PLoS ONE 7, e39698

4. Chun L., Zhang W. & Liu J. (2012) Structure and ligand recognition of class C GPCR. Acta Pharmacologica Sinica 33, 312-23

5. Liu J., Baloucoune G. & Chun L. (2012) Role of palmitoylation modification in G-protein-coupled receptor function. Chinese Journal of Biochemistry and Molecular Biology 2, 99-107

6. Liu J., Chen J., Liu X., Chun L., Tang J. & Deng Y.(2011) Mass segmentation using a combined method for cancer detection. BMC Systems Biology 5, S6

7. Liu X., Liu J., Xu X., Chun L., Tang J. & Deng Y. (2011) A robust detail preserving anisotropic diffusion for speckle reduction in ultrasound images. BMC Genomics 12, S14

8. Song J., Wang X., Chun L., Piao J., Yin C., Zhang Z., Lin Q. & Huang H. (2006) Fusion of chemotactic peptide to a single chain bispecific antibody (ScBsAb) potentiates its cytotoxicity to target tumor cells. Biotechnology and Applied Biochemistry 45, 147-54

9. Chun L., Yin C., Song J., Liu M., Piao J., Lin Q., Wang X. & Huang H. (2004) Soluble expression of recombinant human secondary lymphoid chemokine (SLC) in E. coli and research on its in vivo and in vitro bioactivity. Journal of Biochemistry 136, 769-76

Project

2017-2019                         NSFC Youth Program (31600975): (200000 RMB)

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