Selected Publications
1. Chen, W.H., et al., Energy efficiency trade-offs drive nucleotide usage in transcribed regions. Nat Commun, 2016. 7: p. 11334.
2. He, Z., et al., Evolview v2: an online visualization and management tool for customized and annotated phylogenetic trees. Nucleic Acids Res, 2016.
3. Chen, W.H., van Noort, V., Lluch-Senar, M., Hennrich, M.L., JA, H.W., Yus, E., Alibes, A., Roma, G., Mende, D.R., Pesavento, C. et al. (2016) Integration of multi-omics data of a genome-reduced bacterium: Prevalence of post-transcriptional regulation and its correlation with protein abundances. Nucleic Acids Res, 44, 1192-1202.
4. Lluch-Senar, M., Delgado, J., Chen, W.H., Llorens-Rico, V., O'Reilly, F.J., Wodke, J.A., Unal, E.B., Yus, E., Martinez, S., Nichols, R.J. et al. (2015) Defining a minimal cell: essentiality of small ORFs and ncRNAs in a genome-reduced bacterium. Molecular systems biology, 11, 780.
5. Chen, W.-H., et al., Human Monogenic Disease Genes Have Frequently Functionally Redundant Paralogs. PLoS Comput Biol, 2013. 9(5): p. e1003073.
6. Schonknecht, G., Chen, W.H., Ternes, C.M., Barbier, G.G., Shrestha, R.P., Stanke, M., Brautigam, A., Baker, B.J., Banfield, J.F., Garavito, R.M. et al. (2013) Gene transfer from bacteria and archaea facilitated evolution of an extremophilic eukaryote. Science, 339, 1207-1210.
7. Chen, W.H., Minguez, P., Lercher, M.J. and Bork, P. (2012) OGEE: an online gene essentiality database. Nucleic Acids Research, 40, D901-906.
8. Chen, W.-H., Trachana, K., Lercher, M.J. and Bork, P. (2012) Younger Genes Are Less Likely to Be Essential than Older Genes, and Duplicates Are Less Likely to Be Essential than Singletons of the Same Age. Molecular Biology and Evolution, 29, 1703-1706..
For a more up-to-date and complete list of our publications, please consult: http://chenlab.medgenius.info/publications/.