Fu Chunhua-College of Life Science & Technology

Associate Professor

Phone: 86(27)87792432

Email: fuchunhua@hust.edu.cn

Academic Areas: plant biotechnology

Research Interests: plant secondary metabolism regulation, plant cell scale culture, synthesis biology

Academic Degrees

PhD in Horticulture Science and technology, 2004, Huazhong Agriculture University

BS in Horticulture Science and technology, 1998, Huazhong Agriculture University

Professional Experience

Associate Professor (2006.11-present), Huazhong University of Science and Technology, College of Life Science and Technology;

Visiting scholar (2007.4-2008.5) , Japanese International Research Center for Agricultural Science

Lecturer (2003.9-2006.10), Huazhong University of Science and Technology, College of Life Science and Technology.

Selected Publications

1. Dong YS, Duan WL, He HX, Su P, Zhang M, Song GH, Fu CH*, Yu LJ. Enhancing taxane biosynthesis in cell suspension culture of Taxus chinensis by overexpressing the neutral/alkaline invertase gene. Process biochemistry, 2015, 50(4): 651-660 doi:10.1016/j.procbio.2015.01.018 (corresponding author)

2. Zhang M, DongYS, Nie L, Lu MB, Fu CH*, Yu LJ. High-throughput sequencing reveals miRNA effects on the primary and secondary production properties in long-term subcultured Taxus cells. Frontiers in plant science, 2015, 6: 604 DOI:10.3389/fpls.2015.00604 (corresponding author)

3. Dong YS, Fu CH, Su P, Xu XP, Yuan J, Wang S, Zhang M, Zhao CF, Yu LJ. Mechanisms and well-control of physiological browning phenomena in plant cell cultures. Physiologia Plantarum, 2015, 156(1), p 13-28 DOI: 10.1111/ppl.12382 (co-first author)

4. Li XL, Yuan J, Dong YS, Fu CH*, Li MT, Yu. LJ Optimization of an HPLC Method for Determining the Genomic Methylation Levels of Taxus Cells, Journal of Chromatographic Science, 2016, 54(2): 200-205, doi: 10.1093/chromsci/bmv129 (corresponding author)

5. Miao LY, Zhang LB, Raboanatahiry N, Lu G, Zhang X, Xiang J, Gan J, Fu CH* and Li MT* (2016) Transcriptome Analysis of Stem and Globally Comparison with Other Tissues in Brassica napus. Front. Plant Sci. 7:1403. doi: 10.3389/fpls.2016.01403 (co-corresponding author)

6. Zhang M, Li ST, Nie L, Chen QP, Xu XP, Yu LJ*, Fu CH*. Two jasmonate-responsive factors, TcERF12 and TcERF15, respectively act as repressor and activator of tasy gene of taxol biosynthesis in Taxus chinensis. Plant Mol Biol. 2015, 89(4): 463-473 DOI 10.1007/s11103-015-0382-2 (co-corresponding author)

7. Zhang CY, Dong YS, Li YL, Fu CH*, Zhao CF, Yu LJ*. Unstructured models for suspension cultures of Taxus media cells in a bioreactor under substrate-sufficient. Biochemical Engineering Journal, 2013, 71: 62-71(co-corresponding author)

8. Li ST, Zhang P, Zhang M, Fu CH*, Yu LJ. Functional analysis of a WRKY transcription factor involved in transcriptional activation of DBAT gene in Taxus chinensis. Plant biology，2013, 15: 19-26. doi:10.1111/j.1438-8677.2012.00611.x (corresponding author)

9. Li LQ, Li XL, Fu CH*, Zhao CF, Yu LJ. Sustainable use of high yielding Taxus media cell cultures through minimal growth conservation and manipulation of genome methylation. Process Biochemistry, 2013, 48：525-531. 10.1016/j.procbio.2013.01.013 (corresponding author)

10. Li ST, Zhang P, Zhang M, Fu CH, Zhao CF, Dong YS, Guo AY, Yu LJ*. Transcriptional profile of Taxus chinensis cells in response to methyl jasmonate. BMC genomics, 2012, 13(1): 295- 306 (co-first author)

11. Li ST, Zhang M, Fu CH*, Xie S, Zhang Y, Yu LJ. Molecular Cloning and Characterization of Two 5 9-Lipoxygenase Genes from Taxus chinensis. Plant Mol Biol Rep., 2012, 30(6): 1283-1290. DOI 10.1007/s11105-012-0439-1 SCI B类，IF= 2.453 (corresponding author)

12. Fu CH, Li LQ, Wu Wenjuan, Li Maoteng, Yu XQ, Yu LJ*. Assessment of genetic and epigenetic variation during long-term Taxus cellculture. Plant Cell Reports, 2012, 31 (7): 1321-1331 (first author)

Courses Taught

0707181 General Biology Part Ⅱ (undergraduate)

0704222 metabolic physiology (undergraduate)

170.576 Principle and Technology of Bioengineering (graduate)

Project

1. The molecular regulatory mechanism of miR5298b on taxol biosynthesis in Taxus cells（31670293）. Natural Science Foundation of China, 2017.1-2020.12, Project host

2. The regulatory mechanism of WRKY transcriptioanl factor on the taxol biosynthesis（31270342）, Natural Science Foundation of China, 2013.1-2016.12, Project host

3. The regulatory of DNA methylation on taxol biosynthesis in Taxus cells(200906036), Natural Science Foundation of China, 2010.1-2012.12, Project host

4. Studies on the synthetic biology of the effective way of the taxol mother nucleus(20120142130009), Doctoral Scientific Fund Project of the Ministry of Education of China, 2013.1-2015.12, Project backbone

5. Plant cell culture and large scale transformation（2008BAI63B04）, National Science and technology support program, 2009.1-2012.12, Project backbone

6. Regulation of secondary metabolites in plant cells by inducible expression of transcription factors, Natural Science Foundation of China, 2008.01-2010.12, Project backbone

7. Industrialization of taxol and its precursor production from the branches and leaves of taxus , Civil horizontal project (Technical Development) ,2016.3-2021.3, Project backbone

8. Maca standard cultivation, processing and a series of new product development, Civil horizontal project (Technical Development) , 2013.9-2018.8, Project backbone

9. Construction of unsaturated fatty acid synthesis pathway in Brassica Rape by molecular design method, 863 project, 2007.5-2010.1, Deputy head of the project