Xu Chengqi-College of Life Science & Technology

Associate Professor

Phone: (86)-27-87793502

Email: cqxu@mail.hust.edu.cn

Academic Areas: Cardiovascular Genetics

Research Interests: Genetic and molecular basis of cardiovascular disease and metabolic disease

Academic Degrees

PHD in Biochemistry and Molecular Biology, 2010, Huazhong University of Science and Technology

BA in Biology, 2005, Central China Normal University

Professional Experience

2015-. Associate Professor, Collage of Life Science and Technology, Huazhong University of Science and Technology

2010-2015: Postdoctoral fellow, Collage of Life Science and Technology, Huazhong University of Science and Technology

Selected Publications

1. Lu Q, Yao Y, Hu Z, Hu C, Song Q, Ye J, Xu C, Wang AZ, Chen Q, Wang QK. Angiogenic Factor AGGF1 Activates Autophagy with an Essential Role in Therapeutic Angiogenesis for Heart Disease. PLoS Biol. 2016 14(8):e1002529.

2. Huang Y, Wang Z, Liu Y, Xiong H, Zhao Y, Wu L, Yuan C, Wang L, Hou Y, Yu G, Huang Z, Xu C, Chen Q, Wang QK.αB-Crystallin Interacts with Nav1.5 and Regulates Ubiquitination and Internalization of Cell Surface Nav1.5. J Biol Chem. 2016 291(21):11030-41.

3. Huang Y, Wang C, Yao Y, Zuo X, Chen S, Xu C, Zhang H, Lu Q, Chang L, Wang F, Wang P, Zhang R, Hu Z, Song Q, Yang X, Li C, Li S, Zhao Y, Yang Q, Yin D, Wang X, Si W, Li X, Xiong X, Wang D, Huang Y, Luo C, Li J, Wang J, Chen J, Wang , Wang L, Han M, Ye J, Chen F, Liu J, Liu Y, Wu G, Yang B, Cheng X, Liao Y, Wu Y, Ke T, Chen Q, Tu X, Elston R, Rao S, Yang Y, Xia Y, Wang QK. Molecular Basis of Gene-Gene Interaction: Cyclic Cross-Regulation of Gene Expression and Post-GWAS Gene-Gene Interaction Involved in Atrial Fibrillation. PLoS Genet. 2015 11(8):e1005393.

4. Wang P, Xu C, Wang C, Wu Y, Wang D, Chen S, Zhao Y, Wang X, Li S, Yang Q, Zeng Q, Tu X, Liao Y, Wang QK, Cheng X. Association of SNP Rs9943582 in APLNR with Left Ventricle Systolic Dysfunction in Patients with Coronary Artery Disease in a Chinese Han GeneID Population. PLoS One. 2015 10(5):e0125926.

5. Xu C, Yang Q, Xiong H, Wang L, Cai J, Wang F, Li S, Chen J, Wang C, Wang D, Xiong X, Wang P, Zhao Y, Wang X, Huang Y, Chen S, Yin D, Li X, Liu Y, Liu J, Wang J, Li H, Ke T, Ren X, Wu Y, Wu G, Wan J, Zhang R, Wu T, Wang J, Xia Y, Yang Y, Cheng X, Liao Y, Chen Q, Zhou Y, He Q, Tu X, Wang QK. Candidate Pathway-Based GWAS Identifies Novel Associations of Genomic Variants in the Complement System Associated with Coronary Artery Disease. Circulation Cardiovascular Genetics. 2014 7(6) :887-894.

6. (2) Fan Wang, Cheng-Qi Xu, Qing He, Jian-Ping Cai, Xiu-Chun Li, Dan Wang, Xin Xiong, Yu-Hua Liao, Qiu-Tang Zeng, Xiang Cheng, Yan-Zong Yang, Cong Li, Rong Yang, Chu-Chu Wang, Gang Wu, Qiu-Lun Lu, Ying Bai, Yu-Feng Huang, Dan Yin, Qing Yang, Xiao-Jing Wang , Da-Peng Dai , Rong-Feng Zhang , Jing Wan , Jiang-Hua Ren , Si-Si Li , Yuan-Yuan Zhao , Fen-Fen Fu , Yuan Huang , Qing-Xian Li , Sheng-Wei Shi , Nan Lin , Zhen-Wei Pan , Yue Li , Bo Yu , Yan-Xia Wu , Yu-He Ke , Jian Lei , Nan Wang , Chun-Yan Luo , Li-Ying Ji , Lian-Jun Gao , Lei Li , Hui Liu , Er-Wen Huang , Jin Cui , Xiang Ren , Hui Li , Tie Ke , Xian-Qin Zhang , Jing-Yu Liu , Mu-Gen Liu , Hao Xia , Bo Yang , Li-Song Shi , Yun-Long Xia , Xin Tu& Qing K Wang . Genome-wide association identifies a susceptibility locus for coronary artery disease in the Chinese Han population. Nature Genetics. 2011 43（3）: 345-9

7. Xu C, Wang F, Wang B, Li X, Li C, Wang D, Xiong X, Wang P, Lu Q, Wang X, Yang Q, Yin D, Huang Y, Ji L, Wang N, Chen S, Cheng X, Liao Y, Ma X, Su D, Chen G, Xia H, Shi L, Tu X, Wang QK. Minor Allele C of Chromosome 1p32 SNP rs11206510 Confers Risk of Ischemic Stroke in the Chinese Han Population. Stroke. 2010; 41(8):1587-92.

8. Xiong X, Xu C, Zhang Y, Li X, Wang B, Wang F, Yang Q, Wang D, Wang X, Li S, Chen S, Zhao Y, Yin D, Huang Y, Zhu X, Wang L, Wang L, Chang L, Xu C, Li H, Ke T, Ren X, Wu Y, Zhang R, Wu T, Xia Y, Yang Y, Ma X, Tu X, Wang QK. BRG1 variant rs1122608 on chromosome 19p13. 2 confers protection against stroke and regulates expression of pre-mRNA-splicing factor SFRS3. Human Genetics 2014, 133(5):499-508.

9. Ren X, Xu C, Zhan C, Yang Y, Shi L, Wang F, Wang C, Xia Y, Yang B, Wu G, Wang P, Li X, Wang D, Xiong X, Liu J, Liu Y, Liu M, Liu J, Tu X, Wang QK.Identification of NPPA variants associated with atrial fibrillation in a Chinese GeneID population. Clinica Chimica Acta. 2010；411(7-8):481-5.

10. Li L, Chen D, Li J, Wang X, Wang N, Xu C and Wang QK. (2013) Aggf1 acts at the top of the genetic regulatory hierarchy in specification of hemangioblasts in zebrafish. Blood , 2014, 123(4):501-8.

11. Tu X, Nie S, Liao Y, Zhang H, Fan Q, Xu C, Bai Y, Wang F, Ren X, Tang T, Xia N, Li S, Huang Y, Liu J, Yang Q, Zhao Y, Lv Q, Li Q, Li Y, Xia Y, Qian J, Li B, Wu G, Wu Y, Yang Y, Wang QK, Cheng X. The IL-33-ST2L pathway is associated with coronary artery disease in a Chinese Han population. Am J Hum Genet. 2013 ;93(4):652-60.

12. Cheng X, Shi L, Nie S, Wang F, Li X, Xu C, Wang P, Yang B, Li Q, Pan Z, Li Y, Xia H, Zheng C, Ke Y, Wu Y, Tang T, Yan X, Yang Y, Xia N, Yao R, Wang B, Ma X, Zeng Q, Tu X, Liao Y, Wang QK. The same chromosome 9p21.3 locus is associated with type 2 diabetes and coronary artery disease in a chinesehan population. Diabetes. 2011 60(2):680-4.