Zhu Bin

Academic Degrees

Ph. D., Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 2007

B. Sc., Xiamen University, 2002,

Professional Experience

2016-present, Professor School of Life Science and Technology, Huazhong University of Science and Technology

007-2016, Research Fellow Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School

Selected Publications

1. Zhu B*, Hernandez A, Tan M, Wollenhaupt J, Tabor S, Richardson CC. (2015) Synthesis of 2’-fluoro RNA by Syn5 RNA polymerase. Nucleic Acids Res. 43:e94 (*corresponding author)

2. Zhu B*, Tabor S, Richardson CC. (2014) Syn5 RNA polymerase synthesizes precise run-off RNA products. Nucleic Acids Res. 42: e33 (*corresponding author)

3. Zhu B*, Tabor S, Raytcheva DA, Hernandez A, King JA, Richardson CC*. (2013) The RNA polymerase of marine cyanophage Syn5. J. Biol. Chem. 288(5): 3545-3552 (*corresponding author)

4. Zhu B*, Lee SJ, Tan M, Wang ED, Richardson CC*. (2012) Gene 5.5 protein of bacteriophage T7 in complex with Escherichia coli nucleoid protein H-NS and transfer RNA masks transfer RNA priming in T7 DNA replication. Proc. Natl. Acad. Sci. USA 109(21): 8050-8055 (*corresponding author)

5. Zhu B. (2014) Bacteriophage T7 DNA polymerase - sequenase. Front. Microbiol. 5:181 (Review)

6. Zhu B, Lee SJ, Richardson CC. (2011) Bypass of a nick by the replisome of bacteriophage T7. J. Biol. Chem. 286(32): 28488-28497

7. Zhu B, Lee SJ, Richardson CC. (2010) Direct role for the RNA polymerase domain of T7 primase in primer delivery. Proc. Natl. Acad. Sci. USA 107(20): 9099-9104

8. Zhu B*, Lee SJ*, Richardson CC. (2009) An in trans interaction at the interface of the helicase and primase domains of the hexameric gene 4 protein of bacteriophage T7 modulates their activities. J. Biol. Chem. 284(35): 23842-52381 (*equal contribution)

9. Zhu B*, Yao P*, Tan M*, Eriani G, Wang ED. (2009) tRNA-independent pretransfer editing by class I leucyl-tRNA synthetase. J. Biol. Chem. 284(6): 3418-3424 (*equal contribution)

10. Zhu B, Zhao MW, Eriani G, Wang ED. (2007) A present-day aminoacyl-tRNA synthetase with ancestral editing properties. RNA 13(1): 15-21

11. Zhu B and Wang ED. (2007) Neurodegeneration-related aminoacyl-tRNA synthetases. Prog. Biochem. Biophys. 34(6): 562-566 (Review)

12. Tan M*, Zhu B*, Zhou XL, He R, Chen X, Eriani G, Wang ED. (2010) tRNA-dependent pre-transfer editing by prokaryotic leucyl-tRNA synthetase. J. Biol. Chem. 285(5): 3235-3244 (*equal contribution)

Project

2016 Chinese 1000 Young Talent Program;

2016 NSFC 31670175: Characterization and application of novel phage transcription systems