Professional Experience
09/2012 – 09/2016 Professor and Chair
Department of Nanomedicine and Biopharmaceuticals
Huazhong University of Science and Technology, Wuhan, China
06/2009 – present Professor
National Engineering Research Center for Nanomedicine
Institute of Materia Medica, College of Life Science and Technology
Huazhong University of Science and Technology, Wuhan, China
Adjunct Professor
Department of Medicinal Chemistry
School of Pharmacy
Virginia Commonwealth University
08/2002 – 06/2009 Assistant Professor
Department of Chemistry
Virginia Commonwealth University, Richmond, VA, USA
12/1999 - 08/2002 Post-Doctoral Associate, University of Maryland, College Park, MD, USA
Selected Publications
1. Mosier PD, Chiang M-J, Lin Z, Jin Y, Althufiari B, Musayev F, Safo M, Zhou Q, Xie H*, Desai U R* (2016).Broad spectrum anti-influenza agents by inhibiting self-association of matrix protein 1. Sci Rep 6:32340.
2. Wei Y, Zhao M, Yang F, Mao Y, Xie H, Zhou Q* (2016) Iron overload by Superparamagnetic Iron Oxide Nanoparticles is a High Risk Factor in Cirrhosis by a Systems Toxicology Assessment. Sci Rep 6:29110
3. Zhang D, Liu H, Wei Q, Zhou Q* (2016) Structure-activity relationship study of anticancer thymidine-quinoxaline conjugates under the low radiance of long wavelength ultraviolet light for photodynamic therapy. Eur J Med Chem 107:180-191.
4. Wei Y, Liao R, Liu H, Li H, Xu H, Zhou Q* (2015) Biocompatible Low-retention SPIO Nanoclusters as Contrast Agents for MRI of Liver Tumor. J Biomed Nanotech 11:854-864.
5. Wei Q, Liu H, Zhang D, Zhou H, Zhang Z, Zhou Q* (2015) Anticancer Activity of a Thymidine Quinoxaline Conjugate is Modulated by Cytosolic Thymidine Pathways. BMC Cancer 15:159.
6. Wang X, Wang Z, Sidhu PS, Desai UR, Zhou Q* (2015) 6-Hydroxyflavone and Derivatives Exhibit Potent Anti-inflammatory Activity among Mono-, Di- and Polyhydroxylated Flavones in Kidney Mesangial Cells. PLoS ONE 10:e0116409.
7. Safo MK*, Musayev FN, Mosier PD, Zhou Q, Xie H*, Desai UR (2014) Crystal structures of influenza A virus matrix protein M1: Variations on a theme. PLoS ONE 9:e109510.
8. Sidhu PS, Zhou Q, Desai UR (2014) A simple, general approach of allosteric coagulation enzyme inhibition through monosulfated hydrophobic scaffolds. Bioorg Med Chem Lett 24:5716-5720.
9. Sidhu PS, Abdel AMH, Sarkar A, Mehta AY, Zhou Q, Desai UR* (2013) Designing allosteric regulators of thrombin. Exosite 2 features multiple subsites that can be targeted by sulfated small molecules for inducing inhibition. J Med Chem 56:5059-5070.
10. Mai L, Yao A, Li J, Wei Q, Yuchi M, He X, Ding M, Zhou Q* (2013) Cyanine 5.5 Conjugated Nanobubbles as a Tumor Selective Contrast Agent for Dual Ultrasound-Fluorescence Imaging in a Mouse Model. PLoS ONE 8:e61224.
11. Sidhu PS, Mosier PD, Zhou Q, Desai UR* (2013) On scaffold hopping: Challenges in the discovery of sulfated small molecules as mimetics of glycosaminoglycans. Bioorg Med Chem Lett 23:355-359.
12. Wei Q, Zhang D, Yao A, Mai L, Zhang Z, Zhou Q* (2012) Design, Synthesis, and In vitro and In vivo Biological Studies of a 3’-Deoxythymidine Conjugate that Potentially Kills Cancer Cells Selectively. PLoS ONE 7:e52199.
13. Abdel AMH, Sidhu PS, Liang A, Kim JY, Mosier PD, Zhou Q, Farrell DH, Desai UR* (2012) Designing allosteric regulators of thrombin. Monosulfated benzofuran dimers selectively interact with Arg173 of exosite 2 to induce inhibition. J Med Chem 55:6888-6897.
14. Zhou Q*, Qu Y, Mangrum JB, Wang X (2011) DNA Alkylation with N-Methylquinolinium Quinone Methide to N2-dG Adducts Resulting in Extensive Stops in Primer Extension with DNA Polymerases and Subsequent Suppression of GFP Expression in A549 Cells. Chem Res Toxicol 24:402-411.
15. Sidhu PS, Liang A, Mehta AY, Aziz MA, Zhou Q, Desai UR* (2011) Rational Design of Potent, Small, Synthetic Allosteric Inhibitors of Thrombin J Med Chem 54:5522–31.
